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Journal articles
Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity
Abstract : In this article, we report a convenient and efficient method for the synthesis of new simplified derivatives
of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups
as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor
cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and
Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine.
Cited literature [2 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01080910
Contributor : Muriel Cadieu <>
Submitted on : Friday, November 7, 2014 - 3:32:51 PM
Last modification on : Wednesday, January 13, 2021 - 3:13:38 AM
Long-term archiving on: : Sunday, February 8, 2015 - 10:11:13 AM
Contributor : Muriel Cadieu <>
Submitted on : Friday, November 7, 2014 - 3:32:51 PM
Last modification on : Wednesday, January 13, 2021 - 3:13:38 AM
Long-term archiving on: : Sunday, February 8, 2015 - 10:11:13 AM
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Synthesis of New Simplified He...
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