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Journal articles
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.
Stéphanie Sungalee
1
Emilie Mamessier
1
Ester Morgado
1
Emilie Grégoire
2
Philip Z Brohawn
3
Christopher A Morehouse
3
Nathalie Jouve
1
Céline Monvoisin
4
Cédric Menard
4
Guilhaume Debroas
1
Mustapha Faroudi
1
Violaine Mechin
1
Jean-Marc Navarro
1
Charlotte Drevet
1
Franziska C Eberle
Lionel Chasson
1
Fannie Baudimont
1
Stéphane J Mancini
1
Julie Tellier
1
Jean-Michel Picquenot
5
Rachel Kelly
6
Paolo Vineis
6
Philippe Ruminy
5
Bruno Chetaille
7
Elaine S Jaffe
Claudine Schiff
1
Jean Hardwigsen
2
David A Tice
3
Brandon W Higgs
3
Karin Tarte
4
Bertrand Nadel
1
Sandrine Roulland
1
Stéphanie Sungalee 1
Author
Emilie Mamessier 1
Author IdHAL : emilie-mamessier ORCID : https://orcid.org/0000-0002-3516-0093
Ester Morgado 1
Author
Emilie Grégoire 2
Author
Philip Z Brohawn 3
Author
Christopher A Morehouse 3
Author
Nathalie Jouve 1
Author
Céline Monvoisin 4
Author
Cédric Menard 4
Author
Guilhaume Debroas 1
Author
Mustapha Faroudi 1
Author
Violaine Mechin 1
Author
Jean-Marc Navarro 1
Author
Charlotte Drevet 1
Author
Franziska C Eberle
Author
Lionel Chasson 1
Author
Fannie Baudimont 1
Author
Stéphane J Mancini 1
Author IdHAL : stephane-mancini ResearcherId : http://www.researcherid.com/rid/R-4109-2016 ORCID : https://orcid.org/0000-0001-9255-4606
Julie Tellier 1
Author
Jean-Michel Picquenot 5
Author
Brandon W Higgs 3
Author
Karin Tarte 4
Author
Bertrand Nadel 1
Author
Sandrine Roulland 1
Author IdHAL : sandrine-roulland ORCID : https://orcid.org/0000-0003-2187-1959
1
CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
2
Service de Chirurgie (147 Boulevard Baillé, 13005 Marseille - France)
- APHM - Assistance Publique - Hôpitaux de Marseille (Direction générale AP-HM 80, rue Brochier 13 354 Marseille Cedex 5 - France)
- Hospices Civiles de Marseille (France)
- LA CONCEPTION - Hôpital de la Conception [CHU - APHM] (147 Boulevard Baille 13005 Marseille - France)
3
MedImmune, Inc. (France)
4
MiCa - Microenvironnement et cancer (INSERM UMR917, Campus Santé, Bât 2, Université de Rennes 1, 2 Avenue du Professeur Léon Bernard, 35043 Rennes, France - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U917 (101, rue de Tolbiac, 75013 Paris - France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
5
GPL - Groupe d'étude des proliférations lymphoïdes (Centre Henri Becquerel 1, rue d'Amiens 76038 Rouen cedex - France)
- UNIROUEN - Université de Rouen Normandie (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U918 (101, rue de Tolbiac, 75013 Paris - France)
6
Department of Epidemiology and Public Health (St Mary's Campus, Norfolk Place, London W2 1PG - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
7
CRCM - Centre de Recherche en Cancérologie de Marseille (27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7258 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1068 (101, rue de Tolbiac, 75013 Paris - France)
- Institut Paoli-Calmettes : UMR7258 (France)
- AMU - Aix Marseille Université : UM105 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
Abstract : It has recently been demonstrated that memory B cells can reenter and reengage germinal center (GC) reactions, opening the possibility that multi-hit lymphomagenesis gradually occurs throughout life during successive immunological challenges. Here, we investigated this scenario in follicular lymphoma (FL), an indolent GC-derived malignancy. We developed a mouse model that recapitulates the FL hallmark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cell lymphoma 2 (BCL2) in a subset of B cells, and applied a combination of molecular and immunofluorescence approaches to track normal and t(14;18)+ memory B cells in human and BCL2-overexpressing B cells in murine lymphoid tissues. BCL2-overexpressing B cells required multiple GC transits before acquiring FL-associated developmental arrest and presenting as GC B cells with constitutive activation-induced cytidine deaminase (AID) mutator activity. Moreover, multiple reentries into the GC were necessary for the progression to advanced precursor stages of FL. Together, our results demonstrate that protracted subversion of immune dynamics contributes to early dissemination and progression of t(14;18)+ precursors and shapes the systemic presentation of FL patients.
Document type :
Journal articles
Domain :
Complete list of metadatas
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01083543
Contributor : Laurent Jonchère <>
Submitted on : Monday, November 17, 2014 - 2:18:45 PM
Last modification on : Friday, January 15, 2021 - 3:10:00 AM
Contributor : Laurent Jonchère <>
Submitted on : Monday, November 17, 2014 - 2:18:45 PM
Last modification on : Friday, January 15, 2021 - 3:10:00 AM
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Identifiers
- HAL Id : hal-01083543, version 1
- DOI : 10.1172/JCI72415
- PUBMED : 25384217
Collections
UNIV-RENNES1 | U917 | CNRS | UNIV-AMU | BIOSIT | UR1-UFR-SVE | COMUE-NORMANDIE | MICMAC | UNIV-RENNES | UNIROUEN | CRCM
Citation
Stéphanie Sungalee, Emilie Mamessier, Ester Morgado, Emilie Grégoire, Philip Z Brohawn, et al.. Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.. Journal of Clinical Investigation, American Society for Clinical Investigation, 2014, 124 (12), pp.72415. ⟨10.1172/JCI72415⟩. ⟨hal-01083543⟩
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