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Journal articles
EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature.
Abstract : We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and bearing germinal TP53 gene mutation, also known as Li-Fraumeni syndrome (LFS). We describe for the first time an EGFR-TKI resistance mutation in this population. Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database and from all the published cases of EGFR-mutated lung cancer in TP53 germline mutation carriers.
Cited literature [10 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01092877
Contributor : Marie Lecoupe-Grainville <>
Submitted on : Tuesday, December 9, 2014 - 4:25:30 PM
Last modification on : Wednesday, January 22, 2020 - 3:58:46 PM
Long-term archiving on: : Tuesday, March 10, 2015 - 12:05:35 PM
Contributor : Marie Lecoupe-Grainville <>
Submitted on : Tuesday, December 9, 2014 - 4:25:30 PM
Last modification on : Wednesday, January 22, 2020 - 3:58:46 PM
Long-term archiving on: : Tuesday, March 10, 2015 - 12:05:35 PM
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EFGR-mutant_accepted.pdf
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