EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature. - Archive ouverte HAL Access content directly
Journal Articles Lung Cancer Year : 2015

EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature.

Abstract

We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and bearing germinal TP53 gene mutation, also known as Li-Fraumeni syndrome (LFS). We describe for the first time an EGFR-TKI resistance mutation in this population. Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database and from all the published cases of EGFR-mutated lung cancer in TP53 germline mutation carriers.
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Dates and versions

hal-01092877 , version 1 (09-12-2014)

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Charles Ricordel, Marie Labalette-Tiercin, Alexandra Lespagnol, Mallorie Kerjouan, Catherine Dugast, et al.. EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature.. Lung Cancer, 2015, 87 (1), pp.80-4. ⟨10.1016/j.lungcan.2014.11.005⟩. ⟨hal-01092877⟩
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