On-off closed-loop control of vagus nerve stimulation for the adaptation of heart rate

Abstract : Vagus nerve stimulation (VNS) is a potential therapeutic approach in a number of clinical applications. Although VNS is commonly delivered in an open-loop approach, it is now recognized that closed-loop approaches may be necessary to optimize the therapy and minimize side effects of neuro-stimulation devices. In this paper, we describe a prototype system for real-time control of the instantaneous heart rate, working synchronously with the heart period. As a first step, an on-off control method has been integrated. The system is evaluated on one sheep with induced heart failure, showing the interest of the proposed approach.
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Hector Romero Ugalde, Virginie Le Rolle, Alain Bel, Jean-Luc Bonnet, David Andreu, et al.. On-off closed-loop control of vagus nerve stimulation for the adaptation of heart rate. EMBC: Engineering in Medicine and Biology Conference, Aug 2014, Chicago, United States. pp.6262-6265, ⟨10.1109/EMBC.2014.6945060⟩. ⟨hal-01100914⟩

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