Synthesis of substituted azafluorenones from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes.

Nada Marquise (1) , Vincent Dorcet (1) , Floris Chevallier (1) , Florence Mongin (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

Substituted azafluorenones were synthesized from different dihalogeno diaryl ketones under palladium catalysis by combining either Suzuki or Heck coupling with direct cyclizing arylation. Conditions were identified to allow both auto-tandem processes to proceed successfully from 3-(bromobenzoyl)- or 3-benzoyl-4-bromo-2-chloropyridines, as well as 4-benzoyl-2,3- and 4-benzoyl-2,5-dichloropyridines.

Domains: Chemical Sciences

Nada Marquise, Vincent Dorcet, Floris Chevallier, Florence Mongin. Synthesis of substituted azafluorenones from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes.. Organic & Biomolecular Chemistry, 2014, 12 (41), pp.8138-41. ⟨10.1039/c4ob01629g⟩. ⟨hal-01114406⟩