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Palladium-catalyzed 2,5-diheteroarylation of 2,5-dibromothiophene derivatives.

Abstract : Conditions allowing the one pot 2,5-diheteroarylation of 2,5-dibromothiophene derivatives in the presence of palladium catalysts are reported. Using KOAc as the base, DMA as the solvent and only 0.5-2 mol % palladium catalysts, the target 2,5-diheteroarylated thiophenes were obtained in moderate to good yields and with a wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles, pyrazoles or isoxazoles. Moreover, sequential heteroarylation reactions allow the access to 2,5-diheteroarylated thiophenes bearing two different heteroaryl units.
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Submitted on : Monday, February 9, 2015 - 3:42:08 PM
Last modification on : Wednesday, April 7, 2021 - 3:18:07 PM

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Fatma Belkessam, Aidene Mohand, Jean-François Soulé, Abdelhamid Elias, Henri Doucet. Palladium-catalyzed 2,5-diheteroarylation of 2,5-dibromothiophene derivatives.. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2013, 10, pp.2912-9. ⟨10.3762/bjoc.10.309⟩. ⟨hal-01114548⟩

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