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Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.

Abstract : A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01116168
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Submitted on : Thursday, February 12, 2015 - 4:35:41 PM
Last modification on : Friday, July 10, 2020 - 4:20:16 PM

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Thi Thanh Huyen Trinh, Khanh Hung Nguyen, Patricia de Aguiar Amaral, Nicolas Gouault. Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2012, 9, pp.2042-7. ⟨10.3762/bjoc.9.242⟩. ⟨hal-01116168⟩

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