S. Also-figure, S. References-achatz, G. Nitschke, L. Lamers, and M. C. , Effect of transmembrane and cytoplasmic domains of IgE on the IgE response, Science, vol.276, pp.409-411, 1997.

G. Achatz-straussberger, N. Zaborsky, S. Kö-nigsberger, E. O. Luger, M. Lamers et al., Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR, European Journal of Immunology, vol.169, issue.11, pp.3167-3177, 2008.
DOI : 10.1002/eji.200838456

W. S. Alexander, Suppressors of cytokine signalling (SOCS) in the immune system, Nat. Rev. Immunol, vol.2, pp.410-416, 2002.

R. Amin, C. Carrion, C. Decourt, E. Pinaud, and M. Cogné, Deletion of the ?? immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion, Immunology, vol.413, issue.1, pp.54-63, 2012.
DOI : 10.1111/j.1365-2567.2012.03557.x

URL : https://hal.archives-ouvertes.fr/hal-00696503

F. D. Batista, D. G. Efremov, and O. R. Burrone, Characterization and expression of alternatively spliced IgE heavy chain transcripts produced by peripheral blood lymphocytes, J. Immunol, vol.154, pp.209-218, 1995.

H. D. Brightbill, S. Jeet, Z. Lin, D. Yan, M. Zhou et al., Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice, Journal of Clinical Investigation, vol.120, issue.6, pp.2218-2229, 2010.
DOI : 10.1172/JCI40141DS1

R. L. Coffman, J. Ohara, M. W. Bond, J. Carty, A. Zlotnik et al., B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells, J. Immunol, vol.136, pp.4538-4541, 1986.

F. Colucci, C. Soudais, E. Rosmaraki, L. Vanes, V. L. Tybulewicz et al., Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation, J. Immunol, vol.162, pp.2761-2765, 1999.

I. Dogan, B. Bertocci, V. Vilmont, F. Delbos, J. Mé-gret et al., Multiple layers of B cell memory with different effector functions, Nature Immunology, vol.181, issue.12, pp.1292-1299, 2009.
DOI : 10.1084/jem.20050292

S. Duchez, R. Amin, N. Cogné, L. Delpy, C. Sirac et al., Premature replacement of mu with a immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation, Proc. Natl. Acad. Sci. USA, pp.3064-3069, 2010.

N. Engels, L. M. Kö-nig, C. Heemann, J. Lutz, T. Tsubata et al., Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor???intrinsic costimulation to class-switched B cells, Nature Immunology, vol.32, issue.9, pp.1018-1025, 2009.
DOI : 10.1038/ni.1764

A. Erazo, N. Kutchukhidze, M. Leung, A. P. Christ, J. F. Urban et al., Unique Maturation Program of the IgE Response In Vivo, Immunity, vol.26, issue.2, pp.191-203, 2007.
DOI : 10.1016/j.immuni.2006.12.006

W. A. Figgett, K. Fairfax, F. B. Vincent, L. Page, M. A. Katik et al., The TACI Receptor Regulates T-Cell-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death, Immunity, vol.39, issue.3, pp.573-583, 2013.
DOI : 10.1016/j.immuni.2013.05.019

C. Genton, Y. Wang, S. Izui, B. Malissen, G. Delsol et al., The Th2 Lymphoproliferation Developing in LatY136F Mutant Mice Triggers Polyclonal B Cell Activation and Systemic Autoimmunity, The Journal of Immunology, vol.177, issue.4, pp.2285-2293, 2006.
DOI : 10.4049/jimmunol.177.4.2285

URL : https://hal.archives-ouvertes.fr/hal-00165594

L. Guzman-rojas, J. C. Sims-mourtada, R. Rangel, and H. Martinez-valdez, Life and death within germinal centres: a double-edged sword, Immunology, vol.23, issue.2, pp.167-175, 2002.
DOI : 10.1046/j.1365-2567.2002.01494.x

J. He, M. Meyer-hermann, D. Xiangying, L. Y. Zuan, L. A. Jones et al., B lymphocytes limits their contribution to the classical memory response, The Journal of Experimental Medicine, vol.152, issue.12, pp.2755-2771, 2013.
DOI : 10.1084/jem.20120150

D. Hebenstreit, P. Luft, A. Schmiedlechner, G. Regl, A. Frischauf et al., IL-4 and IL-13 Induce SOCS-1 Gene Expression in A549 Cells by Three Functional STAT6-Binding Motifs Located Upstream of the Transcription Initiation Site, The Journal of Immunology, vol.171, issue.11, pp.5901-5907, 2003.
DOI : 10.4049/jimmunol.171.11.5901

E. K. Holl, B. P. O-'connor, T. M. Holl, K. E. Roney, A. G. Zimmermann et al., Plexin-D1 Is a Novel Regulator of Germinal Centers and Humoral Immune Responses, The Journal of Immunology, vol.186, issue.10, pp.5603-5611, 2011.
DOI : 10.4049/jimmunol.1003464

K. Horikawa, S. W. Martin, S. L. Pogue, K. Silver, K. Peng et al., Enhancement and suppression of signaling by the conserved tail of IgG memory???type B cell antigen receptors, The Journal of Experimental Medicine, vol.160, issue.4, pp.759-769, 2007.
DOI : 10.1093/bioinformatics/bth035

T. Kaisho, F. Schwenk, R. , and K. , The Roles of 1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses, Science, vol.276, issue.5311, pp.412-415, 1997.
DOI : 10.1126/science.276.5311.412

A. Karnowski, G. Achatz-straussberger, C. Klockenbusch, G. Achatz, and M. C. Lamers, Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells, 2006.

B. Li, Q. Hu, R. Xu, H. Ren, E. Fei et al., Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence, BMC Cell Biology, vol.13, issue.1, p.20, 2012.
DOI : 10.1038/cr.2009.6

C. Lutz, B. Ledermann, M. H. Kosco-vilbois, A. F. Ochsenbein, R. M. Zinkernagel et al., IgD can largely substitute for loss of IgM function in B cells, Nature, vol.393, pp.797-801, 1998.

T. Marichal, P. Starkl, L. L. Reber, J. Kalesnikoff, H. C. Oettgen et al., A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom, Immunity, vol.39, issue.5, pp.963-975, 2013.
DOI : 10.1016/j.immuni.2013.10.005

I. Må-rtensson, R. A. Keenan, and S. Licence, The pre-B-cell receptor, Current Opinion in Immunology, vol.19, issue.2, pp.137-142, 2007.
DOI : 10.1016/j.coi.2007.02.006

S. Misaghi, K. Senger, T. Sai, Y. Qu, Y. Sun et al., Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody CSR, Proc. Natl. Acad. Sci. USA, pp.15770-15775, 2013.

M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai et al., Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme, Cell, vol.102, issue.5, pp.553-563, 2000.
DOI : 10.1016/S0092-8674(00)00078-7

I. Oberndorfer, D. Schmid, R. Geisberger, G. Achatz-straussberger, R. Crameri et al., HS1-Associated Protein X-1 Interacts with Membrane-Bound IgE: Impact on Receptor-Mediated Internalization, The Journal of Immunology, vol.177, issue.2, 2006.
DOI : 10.4049/jimmunol.177.2.1139

J. Oh, S. Kim, S. Ahn, L. , and C. , Suppressors of Cytokine Signaling Promote Fas-Induced Apoptosis through Downregulation of NF-??B and Mitochondrial Bfl-1 in Leukemic T Cells, The Journal of Immunology, vol.189, issue.12, pp.5561-5571, 2012.
DOI : 10.4049/jimmunol.1103415

N. W. Palm, R. K. Rosenstein, S. Yu, D. D. Schenten, E. Florsheim et al., Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity, Immunity, vol.39, issue.5, pp.976-985, 2013.
DOI : 10.1016/j.immuni.2013.10.006

S. Pé-ron, B. Laffleur, N. Denis-lagache, J. Cook-moreau, A. Tinguely et al., AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells, Science, vol.336, issue.6083, pp.931-934, 2012.
DOI : 10.1126/science.1218692

M. Poggianella, M. Bestagno, and O. R. Burrone, The Extracellular Membrane-Proximal Domain of Human Membrane IgE Controls Apoptotic Signaling of the B Cell Receptor in the Mature B Cell Line A20, The Journal of Immunology, vol.177, issue.6, pp.3597-3605, 2006.
DOI : 10.4049/jimmunol.177.6.3597

S. L. Pogue and C. C. Goodnow, Gene Dose???Dependent Maturation and Receptor Editing of B Cells Expressing Immunoglobulin (Ig)g1 or Igm/Igg1 Tail Antigen Receptors, The Journal of Experimental Medicine, vol.62, issue.6, pp.1031-1044, 2000.
DOI : 10.1016/1074-7613(95)90048-9

B. Rossi, M. Espeli, C. Schiff, and L. Gauthier, Clustering of Pre-B Cell Integrins Induces Galectin-1-Dependent Pre-B Cell Receptor Relocalization and Activation, The Journal of Immunology, vol.177, issue.2, pp.796-803, 2006.
DOI : 10.4049/jimmunol.177.2.796

URL : https://hal.archives-ouvertes.fr/hal-00085653

M. Sato, T. Adachi, and T. Tsubata, Augmentation of Signaling through BCR Containing IgE but not That Containing IgA Due to Lack of CD22-Mediated Signal Regulation, The Journal of Immunology, vol.178, issue.5, pp.2901-2907, 2007.
DOI : 10.4049/jimmunol.178.5.2901

T. Simmen, Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease, Expert Opinion on Therapeutic Targets, vol.23, issue.3, pp.741-751, 2011.
DOI : 10.1084/jem.191.1.33

R. Sitia, Biosynthesis of membrane and secreted epsilon-chains during lipopolysaccharide-induced differentiation of an IgE+ murine B-lymphoma, 1985.

O. Talay, D. Yan, H. D. Brightbill, E. E. Straney, M. Zhou et al., IgE+ memory B cells and plasma cells generated through a germinal-center pathway, Nature Immunology, vol.134, issue.4, pp.396-404, 2012.
DOI : 10.1002/eji.200635949

C. Wakabayashi, T. Adachi, J. Wienands, and T. Tsubata, A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor, Science, vol.298, issue.5602, pp.2392-2395, 2002.
DOI : 10.1126/science.1076963

L. C. Wu and A. A. Zarrin, The production and regulation of IgE by the immune system, Nature Reviews Immunology, vol.102, issue.4, pp.247-259, 2014.
DOI : 10.1038/nri3632

H. Xiong, J. Dolpady, M. Wabl, M. A. Curotto-de-lafaille, and J. J. Lafaille, Sequential class switching is required for the generation of high affinity IgE antibodies, The Journal of Experimental Medicine, vol.21, issue.2, pp.353-364, 2012.
DOI : 10.1073/pnas.0915072107

Z. Yang, B. M. Sullivan, A. , and C. D. , Fluorescent In??Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition, Immunity, vol.36, issue.5, pp.857-872, 2012.
DOI : 10.1016/j.immuni.2012.02.009