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The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha

Abstract : Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-target organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01119700
Contributor : Valerie Briand <>
Submitted on : Monday, February 23, 2015 - 5:38:52 PM
Last modification on : Monday, June 15, 2020 - 12:00:33 PM

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  • HAL Id : hal-01119700, version 1

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Valeska Contardo-Jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand. The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environmental Pollution, Elsevier, 2010, 158, pp.2059-2066. ⟨hal-01119700⟩

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