Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction. - Archive ouverte HAL Access content directly
Journal Articles Viruses Year : 2011

Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

(1) , (2) , (2)
1
2

Abstract

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.

Dates and versions

hal-01121799 , version 1 (02-03-2015)

Identifiers

Cite

Anna Le Tortorec, Suzanne Willey, Stuart J D Neil. Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.. Viruses, 2011, 3 (5), pp.520-40. ⟨10.3390/v3050520⟩. ⟨hal-01121799⟩
55 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More