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CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells.

Abstract : In follicular lymphoma (FL), follicular helper T cells (TFH) have been depicted as one of the main components of the malignant B-cell niche and a promising therapeutic target. Although defined by their capacity to sustain FL B-cell growth together with specific gene expression and cytokine secretion profiles, FL-TFH constitute a heterogeneous cell population. However, specific markers reflecting such functional heterogeneity are still lacking. In this study, we demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary lymphoid organs. Importantly, this subset is amplified in the FL context, unlike in other B-cell lymphomas with a follicular growth pattern. Furthermore, whereas FL-TFH produce high levels of interleukin (IL)-21 and low levels of IL-17 irrespectively of their CD10 expression, CD10pos FL-TFH specifically exhibit an IL-4hiIFN-γloTNF-αhi cytokine profile associated with a high capacity to sustain directly and indirectly malignant B-cell survival. Altogether, our results highlight the important role of this novel functional subset in the FL cell niche.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01128175
Contributor : Laurent Jonchère <>
Submitted on : Monday, March 9, 2015 - 1:35:21 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:04 AM

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Patricia Amé-Thomas, Sylvia Hoeller, Catherine Artchounin, Jan Misiak, Mounia Sabrina Braza, et al.. CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells.. Blood, American Society of Hematology, 2015, 125 (15), pp.2381 - 2385. ⟨10.1182/blood-2015-02-625152⟩. ⟨hal-01128175⟩

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