Biofilms as a mechanism of bacterial resistance. - Archive ouverte HAL Access content directly
Journal Articles Drug Discovery Today: Technologies Year : 2014

Biofilms as a mechanism of bacterial resistance.

(1) , (1)
1

Abstract

Inside the biofilm, antimicrobial agents must overcome high cell density, an increased number of resistant mutants, substance delivery, molecular exchanges, such as high levels of beta-lactamases or inducers of efflux pump expression, and specific adaptive cells, so-called persisters. The environment within the biofilm modulates the response to antibiotics, especially when the SOS response or DNA repair systems are involved. Exposure to subinhibitory concentrations of antibiotics can enhance biofilm formation and mutagenesis. Thus, a global response to cell stress seems to be responsible for antibiotic-induced biofilm formation.
Not file

Dates and versions

hal-01130308 , version 1 (11-03-2015)

Identifiers

Cite

Anne Jolivet-Gougeon, Martine Bonnaure-Mallet. Biofilms as a mechanism of bacterial resistance.. Drug Discovery Today: Technologies, 2014, 11, pp.49-56. ⟨10.1016/j.ddtec.2014.02.003⟩. ⟨hal-01130308⟩
41 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More