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Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.

Abstract : Objective - The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. Methods - To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. Results - Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. Conclusions - Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
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Contributor : Laurent Jonchère <>
Submitted on : Friday, March 20, 2015 - 2:38:29 PM
Last modification on : Thursday, January 14, 2021 - 11:22:35 AM



Gabriel H Robert, Florence Le Jeune, Clement Lozachmeur, Sophie Drapier, Thibaut Dondaine, et al.. Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.. Neurology, American Academy of Neurology, 2014, 83 (18), pp.1620-6. ⟨10.1212/WNL.0000000000000941⟩. ⟨hal-01133830⟩



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