Skip to Main content Skip to Navigation
Journal articles

Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.

Abstract : The aim of this study was to evaluate the efficacy and safety of bilateral pallidal (GPi) deep brain stimulation (DBS) 6 months after surgery in advanced parkinsonian patients whose dopa-resistant axial motor signs or cognitive decline constituted contraindications for subthalamic nucleus (STN) DBS. Seventeen patients with a mean age of 59.3 ± 7.1 years (range, 45-70), mean disease duration of 12.5 ± 4.3 years (range, 7-20), and contraindications for STN DBS, underwent bilateral GPi DBS. They were evaluated before surgery and 6 months afterward, in accordance with Core Assessment Program for Intracerebral Transplantation recommendations. There were mean improvements of 41.1% in the UPDRS III motor score in the off-dopa condition and 20.3% in the activities of daily living score. Motor fluctuations were reduced by 22.9% and dyskinesias by 68.6%. Axial motor signs improved in the off-dopa condition by 34.2%. Neuropsychological performances remained unchanged at the 6-month assessment. Bilateral GPi DBS is both safe and effective in advanced parkinsonian patients with untreatable motor fluctuations, for whom STN DBS is contraindicated due to dopa-resistant axial motor signs or cognitive decline. As such, it should be regarded as a viable option for these patients.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133911
Contributor : Laurent Jonchère <>
Submitted on : Friday, March 20, 2015 - 4:04:01 PM
Last modification on : Friday, September 6, 2019 - 10:18:02 AM

Links full text

Identifiers

Citation

Tiphaine Rouaud, Thibaut Dondaine, Sophie Drapier, Claire Haegelen, François Lallement, et al.. Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.. Movement Disorders, Wiley, 2010, 25 (12), pp.1839-46. ⟨10.1002/mds.23171⟩. ⟨hal-01133911⟩

Share

Metrics

Record views

89