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Journal articles
Subthalamic nucleus stimulation affects fear and sadness recognition in Parkinson's disease.
Abstract : Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) can produce emotional disorders that have been linked to disturbance of the STN's limbic territory. The aim of this study was to confirm the impairment of the recognition of facial emotions (RFE) induced by STN DBS, not only ruling out the effect of the disease's natural progression in relation to the effect of DBS, but also assessing the influence of modifications in dopamine replacement therapy (DRT) following STN DBS. RFE was investigated in 24 PD patients who underwent STN DBS and 20 PD patients treated with apomorphine. They were assessed 3 months before and after treatment. The 2 patient groups were compared with a group of 30 healthy matched controls. The results showed that RFE for negative emotions (fear and sadness) was impaired in only the STN DBS group in the posttreatment condition and was unrelated to DRT. Results confirm the selective reduction of RFE induced by STN DBS, due neither to the disease's natural progression nor to modifications in DRT.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133918
Contributor : Laurent Jonchère <>
Submitted on : Friday, March 20, 2015 - 4:12:01 PM
Last modification on : Friday, January 15, 2021 - 3:29:15 AM
Contributor : Laurent Jonchère <>
Submitted on : Friday, March 20, 2015 - 4:12:01 PM
Last modification on : Friday, January 15, 2021 - 3:29:15 AM