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Modulation of metabolizing enzymes by bisphenol a in human and animal models.

Abstract : Xenobiotics, such as contaminants and drugs, can be converted to potentially toxic reactive metabolites by phase 1 oxidizing enzymes. These metabolites are further detoxified by phase 2 conjugating enzymes and eliminated from cells by phase 3 transporters. Moreover, many of these xenobiotics are also able to induce or inhibit these enzymes, potentially modulating their own toxicity or that of other chemicals. The present review is focused on bisphenol A, a synthetic monomer used for many industrial applications and exhibiting xenoestrogen properties. The impact of this contaminant on all major classes of metabolizing enzymes (i.e., cytochromes P450, glutathione-S-transferases, sulfotransferases, UDP-glucuronyltransferases, and transporters) was reviewed, with a highlight on the modulation of cytochromes P450 involved in steroid metabolism. Interestingly, most of the studies reported in this review show that BPA is able to induce or inhibit metabolizing enzymes at high doses but also at doses compatible with human exposure.
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, March 24, 2015 - 11:27:02 AM
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Nicolas Quesnot, Simon Bucher, Bernard Fromenty, Marie-Anne Robin. Modulation of metabolizing enzymes by bisphenol a in human and animal models.. Chemical Research in Toxicology, American Chemical Society, 2014, 27 (9), pp.1463-73. ⟨10.1021/tx500087p⟩. ⟨hal-01134758⟩



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