K. Abe, A. Bridges, and K. Brouwer, Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors, Drug Metabolism and Disposition, vol.37, issue.3, pp.447-52, 2009.
DOI : 10.1124/dmd.108.023465

J. Pedersen, P. Matsson, C. Bergstrom, J. Hoogstraate, A. Noren et al., Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11), Toxicological Sciences, vol.136, issue.2, pp.328-371, 2013.
DOI : 10.1093/toxsci/kft197

F. Noor, J. Niklas, U. Muller-vieira, and E. Heinzle, An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells, Toxicology and Applied Pharmacology, vol.237, issue.2, pp.221-252, 2009.
DOI : 10.1016/j.taap.2009.03.011

R. Josse, C. Aninat, D. Glaise, J. Dumont, V. Fessard et al., Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies, Drug Metabolism and Disposition, vol.36, issue.6, pp.1111-1119, 2008.
DOI : 10.1124/dmd.107.019901

S. Antherieu, C. Chesne, R. Li, S. Camus, A. Lahoz et al., Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells, Drug Metabolism and Disposition, vol.38, issue.3, pp.516-541, 2010.
DOI : 10.1124/dmd.109.030197
URL : https://hal.archives-ouvertes.fr/hal-00741715

M. Lubberstedt, U. Muller-vieira, M. Mayer, K. Biemel, F. Knospel et al., HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro, Journal of Pharmacological and Toxicological Methods, vol.63, issue.1, pp.59-68, 2011.
DOI : 10.1016/j.vascn.2010.04.013

K. Kanebratt and T. Andersson, HepaRG Cells as an in Vitro Model for Evaluation of Cytochrome P450 Induction in Humans, Drug Metabolism and Disposition, vol.36, issue.1, pp.137-182, 2008.
DOI : 10.1124/dmd.107.017418

M. Darnell, T. Schreiter, K. Zeilinger, T. Urbaniak, T. Soderdahl et al., Cytochrome P450-Dependent Metabolism in HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor, Drug Metabolism and Disposition, vol.39, issue.7, pp.1131-1139, 2011.
DOI : 10.1124/dmd.110.037721

S. Salerno, C. Campana, S. Morelli, E. Drioli, D. Bartolo et al., Human hepatocytes and endothelial cells in organotypic membrane systems, Biomaterials, vol.32, issue.34, pp.8848-59, 2011.
DOI : 10.1016/j.biomaterials.2011.08.004

A. Skardal, L. Smith, S. Bharadwaj, A. Atala, S. Soker et al., Tissue specific synthetic ECM hydrogels for 3-D in??vitro maintenance of hepatocyte function, Biomaterials, vol.33, issue.18, pp.4565-75, 2012.
DOI : 10.1016/j.biomaterials.2012.03.034

L. Meli, E. Jordan, D. Clark, R. Linhardt, and J. Dordick, Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems, Biomaterials, vol.33, issue.35, pp.9087-96, 2012.
DOI : 10.1016/j.biomaterials.2012.08.065

M. Bhattacharya, M. Malinen, P. Lauren, Y. Lou, S. Kuisma et al., Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture, Journal of Controlled Release, vol.164, issue.3, pp.291-299, 2012.
DOI : 10.1016/j.jconrel.2012.06.039
URL : https://hal.archives-ouvertes.fr/inserm-00864785

Y. Lou, L. Kanninen, T. Kuisma, J. Niklander, L. Noon et al., The Use of Nanofibrillar Cellulose Hydrogel As a Flexible Three-Dimensional Model to Culture Human Pluripotent Stem Cells, Stem Cells and Development, vol.23, issue.4, pp.380-92, 2014.
DOI : 10.1089/scd.2013.0314

D. Klemm, F. Kramer, S. Moritz, T. Lindstrom, M. Ankerfors et al., Nanocelluloses: A New Family of Nature-Based Materials, Angewandte Chemie International Edition, vol.21, issue.543, pp.5438-66, 2011.
DOI : 10.1002/anie.201001273

G. Prestwich, Y. Liu, Y. B. Shu, X. Scott, and A. , 3-D culture in synthetic extracellular matrices: New tissue models for drug toxicology and cancer drug discovery, Advances in Enzyme Regulation, vol.47, issue.1, pp.196-207, 2007.
DOI : 10.1016/j.advenzreg.2006.12.012

J. Vanderhooft, M. Alcoutlabi, J. Magda, and G. Prestwich, Rheological Properties of Cross-Linked Hyaluronan-Gelatin Hydrogels for Tissue Engineering, Macromolecular Bioscience, vol.24, issue.1, pp.20-28, 2009.
DOI : 10.1002/mabi.200800141

P. Gripon, S. Rumin, S. Urban, L. Seyec, J. Glaise et al., Nonlinear partial differential equations and applications: Infection of a human hepatoma cell line by hepatitis B virus, Proceedings of the National Academy of Sciences, vol.99, issue.24, pp.15655-60, 2002.
DOI : 10.1073/pnas.232137699

V. Cerec, D. Glaise, D. Garnier, S. Morosan, B. Turlin et al., Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.103, issue.4, pp.957-67, 2007.
DOI : 10.1002/hep.21536
URL : https://hal.archives-ouvertes.fr/hal-00690471

J. Ye, G. Coulouris, I. Zaretskaya, I. Cutcutache, S. Rozen et al., Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction, BMC Bioinformatics, vol.13, issue.1, 2012.
DOI : 10.1016/0022-2836(70)90057-4

S. Toivonen, M. Ojala, A. Hyysalo, T. Ilmarinen, K. Rajala et al., Comparative Analysis of Targeted Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) and Human Embryonic Stem Cells Reveals Variability Associated With Incomplete Transgene Silencing in Retrovirally Derived hiPSC Lines, STEM CELLS Translational Medicine, vol.4, issue.2, pp.83-93, 2013.
DOI : 10.5966/sctm.2012-0047

M. Mikkola, C. Olsson, J. Palgi, J. Ustinov, T. Palomaki et al., Distinct differentiation characteristics of individual human embryonic stem cell lines, BMC Developmental Biology, vol.6, issue.1, p.40, 2006.
DOI : 10.1186/1471-213X-6-40

M. Malinen, H. Palokangas, M. Yliperttula, and A. Urtti, Peptide Nanofiber Hydrogel Induces Formation of Bile Canaliculi Structures in Three-Dimensional Hepatic Cell Culture, Tissue Engineering Part A, vol.18, issue.23-24, pp.2418-2443, 2012.
DOI : 10.1089/ten.tea.2012.0046

P. Meisenheimer, H. Uyeda, D. Ma, M. Sobol, M. Mcdougall et al., Proluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A Inhibition, Drug Metabolism and Disposition, vol.39, issue.12, pp.2403-2413, 2011.
DOI : 10.1124/dmd.111.041541

C. Aninat, A. Piton, D. Glaise, L. Charpentier, T. Langouet et al., EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS, Drug Metabolism and Disposition, vol.34, issue.1, pp.75-83, 2006.
DOI : 10.1124/dmd.105.006759
URL : https://hal.archives-ouvertes.fr/hal-00702085

Y. Chen, M. Sonnaert, S. Roberts, F. Luyten, and J. Schrooten, Validation of a PicoGreen-Based DNA Quantification Integrated in an RNA Extraction Method for Two-Dimensional and Three-Dimensional Cell Cultures, Tissue Engineering Part C: Methods, vol.18, issue.6, pp.444-52, 2012.
DOI : 10.1089/ten.tec.2011.0304

C. Barth and L. Schwarz, Transcellular transport of fluorescein in hepatocyte monolayers: evidence for functional polarity of cells in culture., Proceedings of the National Academy of Sciences, vol.79, issue.16, pp.4985-4992, 1982.
DOI : 10.1073/pnas.79.16.4985

P. Bravo, V. Bender, and D. Cassio, EfficientIn Vitro vectorial transport of a fluorescent conjugated bile acid analogue by polarized hepatic hybrid WIF-B and WIF-B9 cells, Hepatology, vol.261, issue.2, pp.576-83, 1998.
DOI : 10.1002/hep.510270236

Y. Lai, L. Xing, G. Poda, and Y. Hu, Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles, Drug Metabolism and Disposition, vol.35, issue.6, pp.937-982, 2007.
DOI : 10.1124/dmd.106.013250

P. Godoy, N. Hewitt, U. Albrecht, M. Andersen, N. Ansari et al., Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME, Archives of Toxicology, vol.331, issue.5, pp.1315-530, 2013.
DOI : 10.1007/s00204-013-1078-5
URL : https://hal.archives-ouvertes.fr/hal-00939009

S. Hart, Y. Li, K. Nakamoto, E. Subileau, D. Steen et al., A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues, Drug Metabolism and Disposition, vol.38, issue.6, pp.988-94, 2010.
DOI : 10.1124/dmd.109.031831

P. Gunness, D. Mueller, V. Shevchenko, E. Heinzle, M. Ingelman-sundberg et al., 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies, Toxicological Sciences, vol.133, issue.1, pp.67-78, 2013.
DOI : 10.1093/toxsci/kft021

J. Vartiainen, T. Pohler, K. Sirola, L. Pylkkanen, H. Alenius et al., Health and environmental safety aspects of friction grinding and spray drying of microfibrillated cellulose, Cellulose, vol.37, issue.Suppl.1, pp.775-86, 2011.
DOI : 10.1007/s10570-011-9501-7

K. Ghosh, Z. Pan, E. Guan, S. Ge, Y. Liu et al., Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties, Biomaterials, vol.28, issue.4, pp.671-680, 2007.
DOI : 10.1016/j.biomaterials.2006.09.038

Y. Liu, X. Shu, S. Gray, and G. Prestwich, Disulfide-crosslinked hyaluronangelatin sponge: growth of fibrous tissue in vivo, J Biomed Mater Res A, vol.68, pp.142-151, 2004.

A. Karppinen, T. Saarinen, J. Salmela, A. Laukkanen, M. Nuopponen et al., Flocculation of microfibrillated cellulose in shear flow, Cellulose, vol.14, issue.148, pp.1807-1826, 2012.
DOI : 10.1007/s10570-012-9766-5

M. Paakko, M. Ankerfors, H. Kosonen, A. Nykanen, S. Ahola et al., Enzymatic hydrolysis combined with mechanical shearing and high-pressure homogenization for nanoscale cellulose fibrils and strong gels, Biomacromolecules, vol.8, 2007.

C. Lambert, C. Spire, C. N. Guillouzo, and A. , Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells, Toxicology and Applied Pharmacology, vol.234, issue.3, pp.345-60, 2009.
DOI : 10.1016/j.taap.2008.11.008

L. Vee, M. Jigorel, E. Glaise, D. Gripon, P. Guguen-guillouzo et al., Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line, European Journal of Pharmaceutical Sciences, vol.28, issue.1-2, pp.109-126, 2006.
DOI : 10.1016/j.ejps.2006.01.004
URL : https://hal.archives-ouvertes.fr/hal-00699571

E. Wang, C. Casciano, R. Clement, and W. Johnson, Fluorescent substrates of sister- P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites, Pharmaceutical Research, vol.20, issue.4, pp.537-581, 2003.
DOI : 10.1023/A:1023278211849

N. Feller, H. Broxterman, D. Wahrer, and H. Pinedo, ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion, FEBS Letters, vol.54, issue.2, pp.385-393, 1995.
DOI : 10.1016/0014-5793(95)00677-2

T. Litman, M. Brangi, E. Hudson, P. Fetsch, A. Abati et al., The multidrugresistant phenotype associated with overexpression of the new ABC halftransporter , MXR (ABCG2), J Cell Sci, vol.113, pp.2011-2032, 2000.