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Contrôle de la progression du carcinome hépato-cellulaire par le microenvironnement tumoral [Control of hepatocellular carcinoma progression by the tumor microenvironment].

Abstract : A variety of exogenous and endogenous agents, including toxic compounds, alcohol, drugs and viruses, can cause acute and chronic liver injuries which may lead to inflammation and fibrogenesis. Most hepatocellular carcinomas arise on a fibrotic or cirrhotic liver, and progression of hepatocellular carcinoma is associated with continuous changes in the cellular microenvironment. Extracellular matrix remodelling is a complex process involving synthesis and degradation of matrix components that modulate the fate of cancer cells. Proteases, including matrix metalloproteinases, cleave matrix components and release polypeptide modules with specific biological activities. Knowledge of the cellular and molecular mechanisms involved in extracellular matrix remodelling will open the path to biomarker identification and tailored treatments targeting the liver tumor microenvironment.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134836
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, March 24, 2015 - 1:10:53 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:30 AM

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  • HAL Id : hal-01134836, version 1
  • PUBMED : 23259335

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Bruno Clément. Contrôle de la progression du carcinome hépato-cellulaire par le microenvironnement tumoral [Control of hepatocellular carcinoma progression by the tumor microenvironment].. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2011, 196 (1), pp.75-84. ⟨hal-01134836⟩

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