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Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study

Abstract : BACKGROUND: Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failure patients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity. AIMS: To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up. METHODS: Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)\textgreater100 ng/L or N-terminal pro-BNP (NT-proBNP)\textgreater300 ng/L and left ventricular ejection fraction (LVEF)\textgreater45%. RESULTS: The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P\textless0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2). CONCLUSIONS: Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709).
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01147020
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, April 29, 2015 - 3:00:50 PM
Last modification on : Tuesday, October 20, 2020 - 10:17:16 AM

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Erwan Donal, Lars H. Lund, Emmanuel Oger, Camilla Hage, Hans Persson, et al.. Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study. Archives of cardiovascular diseases, Elsevier/French Society of Cardiology, 2014, 107 (2), pp.112--121. ⟨10.1016/j.acvd.2013.11.002⟩. ⟨hal-01147020⟩

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