Comprendre le débat sur les antidépresseurs dans le traitement de l’épisode dépressif majeur [Understanding the Antidepressant Debate in the Treatment of Major Depressive Disorder] - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Thérapie Année : 2015

Comprendre le débat sur les antidépresseurs dans le traitement de l’épisode dépressif majeur [Understanding the Antidepressant Debate in the Treatment of Major Depressive Disorder]

Résumé

There is a long-standing polemic concerning the usefulness of antidepressants in the treatment of major depressive disorder. In this paper, we propose to highlight some aspects of this controversy by exploring the mutual influence of psychopharmacology and trial methodologies. Indeed, antidepressant efficacy, if not proved, was accepted before antidepressant randomised controlled trials (RCTs) were run. While RCTs became a gold standard to meet the requirements of the regulatory bodies, methodological tools were required to measure outcomes and to test whether antidepressants provide statistically significant benefits as compared with a placebo. All these methodological options have nonetheless introduced fuzziness in our interpretation of study results, in terms of clinical meaningfulness and in terms of transposability to a real life settings. Additionally, selective publication raises concerns about the published literature, and results in many paradoxes. Instead of providing easy answers, the application of the RCT paradigm in MDD raises numerous questions. This is probably in the nature of all scientific studies, but it can be in contradiction with clinicians' expectations, who want to be sure that the treatment will (or will not) work for their individual patients.
Fichier principal
Vignette du fichier
Understanding the Antidepressant Debate - accepted not revised.pdf (134.84 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01147040 , version 1 (23-09-2015)

Identifiants

Citer

Florian Naudet, Rémy Boussageon, Clément Palpacuer, Laurent Gallet, Jean-Michel Reymann, et al.. Comprendre le débat sur les antidépresseurs dans le traitement de l’épisode dépressif majeur [Understanding the Antidepressant Debate in the Treatment of Major Depressive Disorder]. Thérapie, 2015, 9 (19), pp.140028. ⟨10.2515/therapie/2014228⟩. ⟨hal-01147040⟩
235 Consultations
442 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More