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Studies of doped biomimetic nano-hydroxyapatite/polymer matrix composites for applications in biomedical field.

Abstract : Every year, millions of people are suffering from bone defect arising from trauma, tumor or bone diseases. Therefore, there is a growing need for the development of biocomposites with excellent bioactivity and compatibility. In this study, nano-hydroxyapatite was elaborated by using polyvinyl alc. (PVA) and polyvinylpyrrolidone (PVP) under mild temp. condition. Comparison with pure nano-hydroxyapatite prepd. by pptn. method was investigated. The main goal is to highlight the effects of the introduction of polymers on the physico-chem. properties, morphol. and on the chem. reactivity and bioactivity for applications in bony surgery. TEM showed a nanosphere hydroxyapatite with an av. diam. 45 nm obtained by using PVA. Nano-rods HA with an av. dimensions 13 nm width and 156 nm length were obtained by using, PVP "In-vitro" physiol. stability and soly. of the investigated samples was performed by soaking powder in Simulated Body Fluid under physiol. condition. Characterization by XRD, FT-IR SEM-EDS and ICP-OES were performed to identify phases, microstructure and then the chem. reactivity and bioactivity after soaking in SBF to evaluate the bioactivity kinetics. Crystals on the polymer fibril matrix exhibited certain orientation. Bone like apatite layer onto the surfaces is confirmed after post immersion in SBF by FT-IR, SEM-EDS and XRD. The polymer matrix controlled the dissoln. pptn. reactivity with specific rate without change on the pH of the surrounding physiol. body fluid.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01151587
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, May 13, 2015 - 10:43:09 AM
Last modification on : Friday, July 10, 2020 - 4:08:58 PM

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  • HAL Id : hal-01151587, version 1

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Hassane Oudadesse, Amany Mostafa, Xuong-Vuong Bui, Yann Le Gal, Guy Cathelineau. Studies of doped biomimetic nano-hydroxyapatite/polymer matrix composites for applications in biomedical field.. Recent Researches in Modern Medicine, Feb 2011, Cambridge, United Kingdom. pp.368--374. ⟨hal-01151587⟩

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