THEME SERIES - UPR in Cancer

Claudio Hetz (1, 2, 3) , Eric Chevet (4)

1 Department of Immunology and Infectious Diseases
2 Biomedical Neuroscience Institute
3 Institute of Biomedical Sciences
4 OSS - Oncogenesis Stress Signaling

Over the past decade endoplasmic reticulum (ER) stress signaling pathways have collectively emerged as an essential mechanism at the crossroads of the cellular functions involved in key steps of cancer development. ER stress signaling has pleiotropic roles in cancer, and is involved at the level of cell transformation, tumor growth and metastasis as well as resistance to chemo- and radio-therapy. Indeed beyond the instrumental roles of the ER in the biogenesis of secretory and transmembrane proteins...

Domains: Life Sciences [q-bio]

Claudio Hetz, Eric Chevet. THEME SERIES - UPR in Cancer. Seminars in Cancer Biology, 2015, 33, pp.1-2. ⟨10.1016/j.semcancer.2015.04.008⟩. ⟨hal-01151623⟩