Fluorenyl porphyrins for combined two-photon excited fluorescence and photosensitization.

Olivier Mongin (1) , Vincent Hugues (2) , Mireille Blanchard-Desce (2) , Areej Merhi (1) , Samuel Drouet (1) , Dandan Yao (1) , Christine Paul-Roth (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 ISM - Institut des Sciences Moléculaires

The two-photon absorption (2PA), the luminescence and the photosensitization properties of porphyrin-cored fluorenyl dendrimers and meso-substituted fluorenylporphyrin monomer, dimer and trimer are described. In comparison with model tetraphenylporphyrin, these compds. combine enhanced (non-resonant) 2PA cross-sections in the near IR and enhanced fluorescence quantum yields, together with maintained singlet oxygen generation quantum yields. 'Semi-disconnection' between fluorenyl groups and porphyrins (i.e. direct meso substitution) proved to be more efficient than non-conjugated systems (based on efficient FRET between fluorenyl antennae and porphyrins). These results are of interest for combined two-photon imaging and photodynamic therapy.

Mots clés: fluorenyl porphyrin two photon excited fluorescence photosensitization

Domaines: Chimie

Olivier Mongin, Vincent Hugues, Mireille Blanchard-Desce, Areej Merhi, Samuel Drouet, et al.. Fluorenyl porphyrins for combined two-photon excited fluorescence and photosensitization.. Chemical Physics Letters, 2015, 625, pp.151--156. ⟨10.1016/j.cplett.2015.03.003⟩. ⟨hal-01153413⟩