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Detection of Dysplasia or Cancer in 3.5% of Patients with Inflammatory Bowel Disease and Colonic Strictures

Mathurin Fumery 1, 2 Guillaume Pineton Chambrun 3 Carmen Stefanescu 1 Anthony Buisson 4 Aude Bressenot 5 Laurent Beaugerie 6, 7 Aurelien Amiot 8 Romain Altwegg 9 Guillaume Savoye 10, 11, 12, 13 Vered Abitbol 14 Guillaume Bouguen 15, 16 Marion Simon 17 Jean-Pierre Duffas 18 Xavier Hebuterne 19 Stéphane Nancey 20 Xavier Roblin 21 Emmanuelle Leteurtre 22 Gilles Bommelaer 4 Jeremie H. Lefevre 7 Francesco Brunetti 23 Françoise Guillon 9 Yoram Bouhnik 1 Laurent Peyrin-Biroulet 5, *
Abstract : Background: Aims Colonic strictures complicate inflammatory bowel disease (IBD) and often lead to surgical resection to prevent dysplasia or cancer. We assessed the frequency of dysplasia and cancer among IBD patients undergoing resection of a colorectal stricture. Methods We analyzed data from the Groupe d’études et thérapeutiques des affections inflammatoires du tube digestif study. This was a nationwide retrospective study of 12,013 patients with IBD in France who underwent surgery for strictures at 16 centers, from August 1992 through January 2014 (293 patients for a colonic stricture, 248 patients with Crohn’s disease, 51% male, median age at stricture diagnosis was 38 y). Participants had no preoperative evidence of dysplasia or cancer. We collected clinical, endoscopic, surgical, and pathology data and information on outcomes. Results When patients were diagnosed with strictures, they had IBD for a median time of 8 y (3−14 y). The strictures were a median length of 6 cm (4−10 cm) and caused symptoms in 70% of patients. Of patients with Crohn’s disease, 3 were found to have low-grade dysplasia (1%), 1 was found to have high-grade dysplasia (0.4%), and 2 were found to have cancer (0.8%). Of patients with ulcerative colitis, 1 had low-grade dysplasia (2%), 1 had high-grade dysplasia (2%), and 2 had cancer (5%). All patients with dysplasia or cancer received curative surgery, except 1 who died of colorectal cancer during the follow-up period. No active disease at time of surgery was the only factor associated with dysplasia or cancer at the stricture site (odds ratio, 4.86; 95% confidence interval, 1.11–21.27; P=.036). Conclusion In a retrospective study of patients with IBD undergoing surgery for colonic strictures, 3.5% were found to have dysplasia or cancer. These findings can be used to guide management of patients with IBD and colonic strictures.
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Submitted on : Wednesday, November 18, 2015 - 1:02:45 PM
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Mathurin Fumery, Guillaume Pineton Chambrun, Carmen Stefanescu, Anthony Buisson, Aude Bressenot, et al.. Detection of Dysplasia or Cancer in 3.5% of Patients with Inflammatory Bowel Disease and Colonic Strictures. Clinical Gastroenterology and Hepatology, WB Saunders, 2015, 13 (10), pp.1770-1775. ⟨10.1016/j.cgh.2015.04.185⟩. ⟨hal-01154234⟩

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