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Dietary alpha-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs

Abstract : Objective - The pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders. Methods - Glucose tolerance, lipid profile, and oxidant and inflammation status were investigated longitudinally in lean Göttingen minipigs receiving for 16 weeks either a normal diet (ND), a Western diet (WD), or a Western diet supplemented with a whey protein isolate (WPI) rich in α-lactalbumin known to improve glucose tolerance. ND and WD were supplied isoenergetically. Results - Lean minipigs fed WD displayed glucose intolerance and altered lipid profile after 6 weeks of diet but no inflammation or oxidative stress. Supplementation with WPI alleviated glucose intolerance by improving insulin secretion, but not lipid profile. Conclusions - Western diet consumption is deleterious for glucose tolerance even in the absence of fat mass accretion, and dyslipemia is a major determinant for this metabolic dysfunction. Stimulating insulin secretion with a WPI is an effective strategy to improve glucose tolerance.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01159327
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 3, 2015 - 11:10:52 AM
Last modification on : Wednesday, May 27, 2020 - 7:11:51 PM

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Sophie Blat, Sophie Vincent, Luz Lefeuvre-Orfila, Sophie Lemoine-Morel, Charles-Henri Malbert, et al.. Dietary alpha-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs. Obesity, Wiley, 2015, 23 (2), pp.415-421. ⟨10.1002/oby.20990⟩. ⟨hal-01159327⟩

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