Dietary alpha-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs - Archive ouverte HAL Access content directly
Journal Articles Obesity Year : 2015

Dietary alpha-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs

(1) , (2) , (2) , (2) , (1) , (3) , (3) , (2)
1
2
3

Abstract

Objective - The pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders. Methods - Glucose tolerance, lipid profile, and oxidant and inflammation status were investigated longitudinally in lean Göttingen minipigs receiving for 16 weeks either a normal diet (ND), a Western diet (WD), or a Western diet supplemented with a whey protein isolate (WPI) rich in α-lactalbumin known to improve glucose tolerance. ND and WD were supplied isoenergetically. Results - Lean minipigs fed WD displayed glucose intolerance and altered lipid profile after 6 weeks of diet but no inflammation or oxidative stress. Supplementation with WPI alleviated glucose intolerance by improving insulin secretion, but not lipid profile. Conclusions - Western diet consumption is deleterious for glucose tolerance even in the absence of fat mass accretion, and dyslipemia is a major determinant for this metabolic dysfunction. Stimulating insulin secretion with a WPI is an effective strategy to improve glucose tolerance.
Not file

Dates and versions

hal-01159327 , version 1 (03-06-2015)

Identifiers

Cite

Sophie Blat, Sophie Vincent, Luz Lefeuvre-Orfila, Sophie Lemoine-Morel, Charles-Henri Malbert, et al.. Dietary alpha-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs. Obesity, 2015, 23 (2), pp.415-421. ⟨10.1002/oby.20990⟩. ⟨hal-01159327⟩
75 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More