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Aerobic Training Suppresses Exercise-induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls

Abstract : This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. Thirty-nine adolescent girls (14-19 years old) were classified as non-obese or overweight/obese and then randomly assigned to either the non-trained or trained group (12-week multivariate aerobic training program). Measurements at the beginning of the experiment and at 3 months consisted of body composition, aerobic fitness (VO2peak) and the following blood assays: pre- and post-exercise lipid peroxidation (15F2?-isoprostanes [F2-Isop], lipid hydroperoxide [ROOH], oxidized LDL [ox-LDL]) and inflammation (myeloperoxidase [MPO]) markers. In the overweight/obese group, the training program significantly increased their fat-free mass (FFM) and decreased their percentage of fat mass (%FM) and hip circumference but did not modify their VO2peak. Conversely, in the non-trained overweight/obese group, weight and %FM increasedand VO2peak decreased, during the same period. Training also prevented exercise-induced lipid peroxidation and/or inflammation in overweight/obese girls (F2-Isop, ROOH, ox-LDL, MPO). In addition, in the trained overweight/obese group, exercise-induced changes in ROOH, ox-LDL and F2-Isop were correlated with improvements in anthropometric parameters (waist-to-hip ratio, %FM and FFM). In conclusion aerobic training increased tolerance to exercise-induced oxidative stress in overweight/obese adolescent girls partly as a result of improved body composition.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01159358
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 3, 2015 - 11:13:39 AM
Last modification on : Wednesday, April 22, 2020 - 12:08:24 PM

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C Groussard, H Youssef, , J Pincemail, C Jacob, et al.. Aerobic Training Suppresses Exercise-induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls. Pediatr Exerc Sci., 2015, 27 (1), pp.67-76. ⟨10.1123/pes.2014-0008⟩. ⟨hal-01159358⟩

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