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Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).

Abstract : One of the main factor involved neuromyopathy acquired in intensive care unit (ICU) appears to be sepsis. It induces the release of many pro- and anti-inflammatory factors which can directly modulate the muscle excitability. We have studied the effects of one of them: the ciliary nervous trophic factor (CNTF) which is a cytokine released in the early phase of sepsis. CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential. These effects could participate to the hypo-excitability observed during sepsis and could be involved in the ICU acquired neuromyopathy. As for TNF?, this early effect is mainly mediated by protein kinase C (PKC) activation and appears to be a reversible post-transcriptional effect.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01159372
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 3, 2015 - 11:17:30 AM
Last modification on : Friday, June 12, 2020 - 5:02:04 PM

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Emilie Guillard, Gildas Gueret, Maïté Guillouët, Véronique Vermeersch, Fabrice Rannou, et al.. Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).. Cytokine, Elsevier, 2013, 63 (1), pp.52--57. ⟨10.1016/j.cyto.2013.04.023⟩. ⟨hal-01159372⟩

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