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Effect of physical activity on human prostate cancer cells proliferation: involvement of oxidative stress?

Abstract : Prostate cancer constitutes a growing health concern which affects men in the Western world and it represents the first cause of death by cancer in France. Among the various origins of prostate cancer, sedentarity represents an important risk factor and a decrease of prostate cancer prevalence is associated with exercise. Physical activity is known to slow down and to prevent some cancers, preferentially breast and colon cancers (Kesaniemi et al., 2001; Leitzmann et al., 2007). However, studies concerning its effects in prostate cancer progression are today conflicting and conclusions are difficult to reach since there remains a lack of clarity on activity parameters (in terms of type, intensity, frequency and time). Recently, Farahmand and coll., have suggested that golf enhances the life expectancy about 5 years (adjusted by age, sex and socioeconomic status of subjects). This physical activity which numbered more than 410 377 members in France today corresponds mainly to a walking sport but it attracts more players. Golf could be suitable for men with low risk early stage prostate cancer during active surveillance. The objectives of this study are (1) to determine if physical activity (golf) has an effect on the in vitro proliferation of human prostate cancer cells and (2) to identify the involved molecular mechanisms. Oxidative stress (OS) phenotypes leading to an imbalance of pro/anti-oxidant in favor of pro-oxidant could play a role in the prostate tumorigenesis (reviewed by Khandrika and al., on 2009). The regular physical activity known to increase antioxidant defenses could reduce the evolution of the prostate cancer through OS-dependent signaling pathways. Serum of sedentary or golfers subjects (3 golf courses 18 holes/week, ? 9 MET-h/week) is incubated with LNCaP androgen-dependent human prostate cancer cells. Proliferation, cell death (necrosis and apoptosis) as well as molecular mechanisms are studied, mainly those dependent of OS. We demonstrate that golfers' serum inhibits the LNCaP cells proliferation without inducing cell death. This inhibition of proliferation doesn’t depend on oxidative stress since no difference between the antioxidant status of sedentary serum and golfer serum appears. Golf could reduce the proliferation of prostate cancer cells in vitro but the preliminary results require further investigations.
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Submitted on : Wednesday, June 3, 2015 - 11:26:02 AM
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  • HAL Id : hal-01159414, version 1


Jordan Guéritat, Amélie Rébillard. Effect of physical activity on human prostate cancer cells proliferation: involvement of oxidative stress?. 20th International Congress on sports sciences for students, Budapest, 2012, 2012, Budapest, Hungary. ⟨hal-01159414⟩



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