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Yttrium-90 microsphere radioembolization for hepatocellular carcinoma

Abstract : Yttrium-90 (Y90) radioembolization is an emerging strategy to treat liver malignancies, and clinical data supporting its use have accumulated in recent years. Y90-radioembolization has shown clinical effectiveness in intermediate and advanced hepatocellular carcinoma, with a favorable safety profile. Retrospective data show similar levels of effectiveness to transarterial chemoembolization in intermediate hepatocellular carcinoma, with some evidence of better tolerance. While phase 3 studies comparing Y90-radioembolization to chemoembolization in intermediate hepatocellular carcinoma would be difficult to conduct, studies comparing or combining Y90-radioembolization with sorafenib are under way. Questions also remain about the most suitable modalities for defining the dose to administer. Phase 3 studies are under way to clarify the place of Y90-radioembolization in the algorithm of HCC treatment
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01162379
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, June 10, 2015 - 1:09:07 PM
Last modification on : Wednesday, March 11, 2020 - 10:31:36 AM

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Julien Edeline, Marine Gilabert, Etienne Garin, Eveline Boucher, Jean-Luc Raoul. Yttrium-90 microsphere radioembolization for hepatocellular carcinoma. Liver Cancer, 2015, 4 (1), pp.16--25. ⟨10.1159/000343878⟩. ⟨hal-01162379⟩

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