Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study - Université de Rennes Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2015

Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study

Résumé

BACKGROUND & AIMS: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). METHODS: We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. RESULTS: The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p\textless0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies

Dates et versions

hal-01162388 , version 1 (10-06-2015)

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Caroline Jezequel, Fabrice Lainé, Bruno Laviolle, Anita Kiani, Edouard Bardou-Jacquet, et al.. Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study. PLoS ONE, 2015, 10 (6), pp.e0128530. ⟨10.1371/journal.pone.0128530⟩. ⟨hal-01162388⟩
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