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The association of body shape trajectories over the life course with type 2 diabetes risk in adulthood: a group-based modeling approach

Abstract : Purpose - Low birth weight is a well-recognized risk factor for type 2 diabetes (T2D), but less is known about risks associated with the evolution of body shape throughout life with incident T2D in adulthood. Methods - In 80,110 women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort study, trajectories of self-reported body shapes from age 8 years to 35-40 years were derived using a group-based modeling approach and studied in relation with incident T2D. Results - Compared with women who maintained a stable midrange body shape trajectory from 8 to 40 years, women in all other observed trajectories were at a higher risk of developing T2D in adulthood: The highest risk was observed for women who were lean at age 8 years and had a sharp increase in body shape (hazards ratio = 2.91 [2.35-3.62]); their T2D risk was higher (P for homogeneity = .059) than for women who maintained the largest body shape (hazards ratio = 2.18 [1.76-2.69]). Conclusions - A group-based modeling approach has identified trajectories of body shape evolution with different risks of developing T2D in adulthood. A sharp increase in body shape after puberty in previously lean girls is a risk factor for the subsequent development of diabetes.
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Submitted on : Thursday, November 19, 2015 - 12:28:11 PM
Last modification on : Monday, November 30, 2020 - 1:44:48 PM

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Guy Fagherazzi, Alice Vilier, Aurélie Affret, Beverley Balkau, Fabrice Bonnet, et al.. The association of body shape trajectories over the life course with type 2 diabetes risk in adulthood: a group-based modeling approach. Annals of Epidemiology, Elsevier Masson, 2015, 25 (10), pp.785-787. ⟨10.1016/j.annepidem.2015.06.002⟩. ⟨hal-01166300⟩

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