Genetic determinants associated with cfxA-positive clinical Capnocytophaga isolates

Abstract : Sir,Capnocytophaga spp. have a role in the pathogenesis of various forms of periodontal disease and systemic infections, particularly severe in neutropenic cancer patients. The prevalence of β-lactam-resistant oral bacteria is increasing in clinical isolates [1]. All of the reported β-lactam-resistant Capnocytophaga isolates are β-lactamase-producers, but minimum inhibitory concentrations (MICs) for the different β-lactams are variable [2]. The objective of the current study was therefore to explain the variability in β-lactam MIC profiles in 31 cfxA gene-positive oral Capnocytophaga spp. clinical isolates with various antibiotypes...