Genetic determinants associated with cfxA-positive clinical Capnocytophaga isolates

Zohreh Tamanai-Shacoori (1) , Anais Dupont (1) , Manon Auffret (1) , Vincent Peton (1) , Frédérique Barloy-Hubler (2) , Elodie Ehrmann (3) , Martine Ropert (4, 5) , Martine Bonnaure-Mallet (1) , Anne Jolivet-Gougeon (1)

1 Microbiologie : Risques Infectieux
2 IGDR - Institut de Génétique et Développement de Rennes
3 UNS UFR Odontologie - Université Nice Sophia Antipolis - Faculté de Chirurgie Dentaire
4 Centre de référence des surcharges en fer rares d'origine génétique
5 Foie, métabolismes et cancer

Sir,Capnocytophaga spp. have a role in the pathogenesis of various forms of periodontal disease and systemic infections, particularly severe in neutropenic cancer patients. The prevalence of β-lactam-resistant oral bacteria is increasing in clinical isolates [1]. All of the reported β-lactam-resistant Capnocytophaga isolates are β-lactamase-producers, but minimum inhibitory concentrations (MICs) for the different β-lactams are variable [2]. The objective of the current study was therefore to explain the variability in β-lactam MIC profiles in 31 cfxA gene-positive oral Capnocytophaga spp. clinical isolates with various antibiotypes...

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire

Zohreh Tamanai-Shacoori, Anais Dupont, Manon Auffret, Vincent Peton, Frédérique Barloy-Hubler, et al.. Genetic determinants associated with cfxA-positive clinical Capnocytophaga isolates. International Journal of Antimicrobial Agents, 2015, 46 (3), pp.356-358. ⟨10.1016/j.ijantimicag.2015.05.006⟩. ⟨hal-01166301⟩