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Osteoinduction and antiosteoporotic performance of hybrid biomaterial chitosan-bioactive glass graft: effects on bone remodeling

Abstract : Osteoinductive and antiosteroporotic phenomena could be created by using synthetic biomaterials for applications in bone surgery. In the present study, CH-based bioactive glass (BG-CH) with 17 wt% chitosan was elaborated by a freeze-drying process. BG-CH was implanted in the muscle and in the femoral condyles of ovariectomized rats. Grafted tissues were carefully removed for physico-chem. and histol. anal. Several physic-chem. techniques (XRD, FT-IR, MEB, ICP-OES and NMR) were employed to highlight the effects of chitosan on the glass matrix before and after implantation. The results of the study show that despite the non-addnl. osteogenic cells or agents, BG-CH is endowed with an osteoinductive property. After 8 wk, 13C NMR spectra showed the characteristic signals of γ-carbons of the hydroxyproline (71 ppm) abundant in collagen. γ-carboxyglutamate (55 ppm), which occurs in several other bone proteins like osteocalcin, indicating the BG-CH degrdn. and the dominance of the bone tissue formation. Moreover, this study showed a rise in Ca and P ion concns. in the implanted microenvironment, leading to the formation/deposition of Ca-P phases. Trace elements such as Zn and Fe were detected in the newly-formed bone and involved in the bone healing. The study highlights the suitability and the extensive applications of BG-CH composites and the clin. useful therapy in regenerative medicine.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01169305
Contributor : Laurent Jonchère <>
Submitted on : Monday, June 29, 2015 - 10:45:31 AM
Last modification on : Saturday, July 11, 2020 - 3:16:13 AM

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S. Jebahi, H. Oudadesse, F. Z. Faouzi, J. Elleuch, T. Rebai, et al.. Osteoinduction and antiosteoporotic performance of hybrid biomaterial chitosan-bioactive glass graft: effects on bone remodeling. Journal of Material Sciences & Engineering, 2013, 2, pp.1--8. ⟨10.4172/2169-0022.1000128⟩. ⟨hal-01169305⟩

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