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Perinatal exposure to chlordecone and infant growth

Abstract : Background The intensive use of chlordecone (an organochlorine insecticide) in the French West Indies until 1993 resulted in a long-term soil and water contamination. Chlordecone has known hormonal properties and exposure through contaminated food during critical periods of development (gestation and early infancy) may affect growth. Objectives We aimed to assess the impact of prenatal and postnatal exposure to chlordecone on the growth of children from the TIMOUN mother–child cohort. Methods Chlordecone was determined in cord plasma at birth (N=222) and in breast milk samples (at 3 months). Dietary chlordecone intake was estimated at 7 and 18 months, with food-frequency questionnaires and food-specific contamination data. Anthropometric measurements were taken at the 3-, 7- and 18-month visits and measurements reported in the infants' health records were noted. Structured Jenss–Bayley growth models were fitted to individual height and weight growth trajectories. The impact of exposure on growth curve parameters was estimated directly with adjusted mixed non-linear models. Weight, height and body mass index (BMI), and instantaneous height and weight growth velocities at specific ages were also analyzed relative to exposure. Results Chlordecone in cord blood was associated with a higher BMI in boys at 3 months, due to greater weight and lower height, and in girls at 8 and 18 months, mostly due to lower height. Postnatal exposure was associated with lower height, weight and BMI at 3, 8 and 18 months, particularly in girls. Conclusion Chlordecone exposure may affect growth trajectories in children aged 0 to 18 months
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01169790
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, June 30, 2015 - 11:27:35 AM
Last modification on : Wednesday, June 17, 2020 - 4:40:17 PM

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Nathalie Costet, Fabienne Pelé, Emmanuelle Comets, Florence Rouget, Christine Monfort, et al.. Perinatal exposure to chlordecone and infant growth. Environmental Research, Elsevier, 2015, 142, pp.123--134. ⟨10.1016/j.envres.2015.06.023⟩. ⟨hal-01169790⟩

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