Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions

Élodie Brun (1) , Abdelmounaim Safer (2) , François Carreaux (1) , Khadidja Bourahla (3) , Jean-Martial L'Helgoua'Ch (1) , Jean-Pierre Bazureau (1) , Jose Manuel Villalgordo

1 ISCR - Institut des Sciences Chimiques de Rennes
2 LSCT - Laboratoire Synthèse et Catalyse [Tiaret]
3 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups

Keywords: boric acid; catalysis; condensation reaction; microwave; solvent-free

Domains: Chemical Sciences

Élodie Brun, Abdelmounaim Safer, François Carreaux, Khadidja Bourahla, Jean-Martial L'Helgoua'Ch, et al.. Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions. Molecules, 2015, 20 (6), pp.11617--11631. ⟨10.3390/molecules200611617⟩. ⟨hal-01174893⟩