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Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates

Abstract : Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174899
Contributor : Laurent Jonchère <>
Submitted on : Friday, July 10, 2015 - 10:40:02 AM
Last modification on : Friday, July 10, 2020 - 4:24:39 PM

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Yari Cabezas, Laurent Legentil, Florence Robert-Gangneux, Franck Daligault, Sorya Belaz, et al.. Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 13 (31), pp.8393-8404 ⟨10.1039/c5ob00563a⟩. ⟨hal-01174899⟩

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