Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates

Yari Cabezas , Laurent Legentil (1) , Florence Robert-Gangneux (2, 3) , Franck Daligault (4) , Sorya Belaz (3, 2) , Caroline Nugier-Chauvin (5, 1) , Sylvain Tranchimand (1) , Charles Tellier (4) , Jean-Pierre Gangneux (3, 2) , Vincent Ferrières (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 Service de Parasitologie-Mycologie [Rennes]
3 Irset - Institut de recherche en santé, environnement et travail
4 UFIP - Unité de fonctionnalité et ingénierie de protéines
5 UEB - Université européenne de Bretagne - European University of Brittany

Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents

Domains: Chemical Sciences

Yari Cabezas, Laurent Legentil, Florence Robert-Gangneux, Franck Daligault, Sorya Belaz, et al.. Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates. Organic & Biomolecular Chemistry, 2015, 13 (31), pp.8393-8404. ⟨10.1039/c5ob00563a⟩. ⟨hal-01174899⟩