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Diazo ester insertion in N-H bonds of amino acid derivatives and insulin catalyzed by water-soluble iron and ruthenium porphyrin complexes (FeTSPPCl) as application of carbenoid transfer in aqueous media

Abstract : The metal complex FeTSPPCl (5,10,15,20-tetrakis)-(4-sulfonato-phenyl)-porphyrin-iron(III) chloride is an active catalyst for carbenoid insertion in N–H bonds of aminoacid derivatives in aqueous media. A variety of diazoacetates and methyl diazophosphonate were used as carbenoid precursors. The commercially available iron porphyrin complex can also selectively catalyze alkylation of the N-terminus of insulin (chain B)
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Submitted on : Tuesday, September 22, 2015 - 1:06:14 PM
Last modification on : Friday, July 10, 2020 - 4:10:09 PM
Long-term archiving on: : Tuesday, December 29, 2015 - 7:18:40 AM

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Hassan F. Srour, Paul Le Maux, Soizic Chevance, Daniel Carrié, Nicolas Le Yondre, et al.. Diazo ester insertion in N-H bonds of amino acid derivatives and insulin catalyzed by water-soluble iron and ruthenium porphyrin complexes (FeTSPPCl) as application of carbenoid transfer in aqueous media. Journal of Molecular Catalysis A: Chemical, Elsevier, 2015, 407, pp.194-203. ⟨10.1016/j.molcata.2015.06.028⟩. ⟨hal-01174902⟩

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