sp3 C–H Bond Functionalization with Ruthenium Catalysts

Christian Bruneau (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

The selective formation of carbon–carbon bond by functionalization of an sp3C–H bond is still a challenge in organic synthesis. There are already examples involving transition metal catalysis. In this chapter we review the use of ruthenium(0) and ruthenium(II) catalysts for the formation of carbon–carbon bonds based on creation of reactive sites by sp3C–H bond activation. We show that in most cases, regioselective sp3C–H bond activation is induced either from functional substrates bearing a directing group, which strongly coordinates the metal centre, or by selective C–H bond activation at the α-carbon of a heteroatom accompanied by hydrogen transfer processes and transient creation of reactive functional groups

Mots clés: Carbon–carbon bond formation; Catalysis; Industrial Chemistry/Chemical Engineering; Organometallic Chemistry; Ruthenium catalysis; sp3C–H activation

Domaines: Chimie

Christian Bruneau. sp3 C–H Bond Functionalization with Ruthenium Catalysts. Dixneuf; Pierre H. and Bruneau; Christian (ed). Ruthenium in Catalysis, 48, Springer International Publishing, pp.195--236, 2014, Topics in Organometallic Chemistry, 978-3-319-08481-7, 978-3-319-08482-4. ⟨10.1007/3418_2014_79⟩. ⟨hal-01174906⟩