Cyclisation reaction between 3-methylquinoxaline-2-thione and benzaldehydes into 3-benzyl-2-aryl-thieno[2,3-b]quinoxaline promoted by Brønsted acids

Besma Saoudi , Abderrahmane Teniou , Adbelmadjid Debache , Thierry Roisnel (1) , Jean-François Soulé (1) , Henri Doucet (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

2,3-Disubstituted thieno[2,3-b]quinoxaline derivatives have been synthetized through the condensation of commercially available benzaldehydes with 3-methylquinoxaline-2-thione in EtOH using Brønsted acids, namely sulfuric or hydrochloric acids. A wide range of substituted benzaldehydes has been used, allowing the formation of 3-(substituted)benzyl-2-arylthieno[2,3-b]quinoxalines in high yields in only one step

Keywords: Acide de Brønsted; Benzaldehydes; Brønsted Acid; Cyclisation; Heterocycles; Quinoxalines; Quinoxalinesés

Domains: Chemical Sciences

Besma Saoudi, Abderrahmane Teniou, Adbelmadjid Debache, Thierry Roisnel, Jean-François Soulé, et al.. Cyclisation reaction between 3-methylquinoxaline-2-thione and benzaldehydes into 3-benzyl-2-aryl-thieno[2,3-b]quinoxaline promoted by Brønsted acids. Comptes Rendus. Chimie, 2015, 18 (8), pp.808--815. ⟨10.1016/j.crci.2015.06.003⟩. ⟨hal-01188181⟩