Dendritic molecular assemblies for singlet oxygen generation: meso-tetraphenylporphyrin-based biphotonic sensitizers with remarkable luminescence

Dandan Yao (1) , Vincent Hugues (2) , Mireille Blanchard-Desce (2) , Olivier Mongin (1) , Christine O. Paul-Roth (1) , Frédéric Paul (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 ISM - Institut des Sciences Moléculaires

Four new TPP-based chromophores (1-4) peripherally functionalized with dendrons contg. 2-fluorenyl groups were studied for their potential to serve in photodynamic therapy. Their linear and nonlinear optical properties were investigated. With significant TPA cross-sections at 790 nm, good singlet oxygen generation capabilities and relatively large intrinsic fluorescence, sensitizers such as 1 might become particularly appealing for theranostics.

Domaines: Chimie; Matériaux; Catalyse

Dandan Yao, Vincent Hugues, Mireille Blanchard-Desce, Olivier Mongin, Christine O. Paul-Roth, et al.. Dendritic molecular assemblies for singlet oxygen generation: meso-tetraphenylporphyrin-based biphotonic sensitizers with remarkable luminescence. New Journal of Chemistry, 2015, 39 (10), pp.7730-7733. ⟨10.1039/C5NJ01381J⟩. ⟨hal-01188183⟩