Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole - Archive ouverte HAL Access content directly
Journal Articles Catalysis Communications Year : 2015

Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole

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Abstract

We report, herein, on palladium-catalyzed direct arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole moieties, which don't act as directing groups. With moderate electron-withdrawing substituents on the aryl bromides as coupling partners, the reaction proceeds nicely using phosphine-free PdCl2 catalyst, and potassium pivalate/dimethylacetamide (PivOK/DMA) as catalytic system. The reaction was regioselective and occurred at the less hindered ortho-positions of fluorine or chlorine atoms
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Dates and versions

hal-01188221 , version 1 (22-09-2015)

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Fatma Abdellaoui, Hamed Ben Ammar, Jean-François Soulé, Henri Doucet. Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole. Catalysis Communications, 2015, 71, pp.13--16. ⟨10.1016/j.catcom.2015.07.025⟩. ⟨hal-01188221⟩
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