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Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole

Abstract : We report, herein, on palladium-catalyzed direct arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole moieties, which don't act as directing groups. With moderate electron-withdrawing substituents on the aryl bromides as coupling partners, the reaction proceeds nicely using phosphine-free PdCl2 catalyst, and potassium pivalate/dimethylacetamide (PivOK/DMA) as catalytic system. The reaction was regioselective and occurred at the less hindered ortho-positions of fluorine or chlorine atoms
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01188221
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Submitted on : Tuesday, September 22, 2015 - 9:48:30 AM
Last modification on : Wednesday, October 21, 2020 - 3:13:52 AM
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Fatma Abdellaoui, Hamed Ben Ammar, Jean-François Soulé, Henri Doucet. Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole. Catalysis Communications, Elsevier, 2015, 71, pp.13--16. ⟨10.1016/j.catcom.2015.07.025⟩. ⟨hal-01188221⟩

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