Palladium-Catalysed Direct Arylation using Free-Amine-Substituted Polyfluoroanilines with Inhibition of Amination-Type Reaction

Abdelilah Takfaoui (1, 2) , Rachid Touzani (3, 1) , Jean-François Soulé (2) , Pierre H. Dixneuf (2) , Henri Doucet (2)

1 LCAE - Laboratoire de Chimie Appliquée et Environnement | Laboratory of Applied and Environmental Chemistry [Université Mohammed Premier Oujda]
2 ISCR - Institut des Sciences Chimiques de Rennes
3 Faculté Pluridisciplinaire de Nador

The palladium-catalyzed C-C bond formation via direct arylation of free-amine-substituted polyfluoroaniline derivs. proceeds in moderate to high yields with a variety of aryl bromides. The nature of the base was found to be crucial to promote the direct arylation with inhibition of the amination reaction.

Domains: Chemical Sciences

Abdelilah Takfaoui, Rachid Touzani, Jean-François Soulé, Pierre H. Dixneuf, Henri Doucet. Palladium-Catalysed Direct Arylation using Free-Amine-Substituted Polyfluoroanilines with Inhibition of Amination-Type Reaction. Asian Journal of Organic Chemistry, 2015, 4 (10), pp.1085-1095. ⟨10.1002/ajoc.201500268⟩. ⟨hal-01188225⟩