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Journal articles
Efficiency of Industrially Relevant Atropisomeric Diphosphines in Copper-Catalyzed 1,4-Asymmetric Conjugate Addition of Dialkylzincs to Cyclic or Acyclic Enones or Dienones
Abstract : Industrially relevant atropisomeric diphosphines such as 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), 6,6'-bis(diphenylphosphino)-2,2',3,3'-tetrahydro-5,5'-bi-1,4-benzodioxin (SYNPHOS), and 5,5'-bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole (DIFLUORPHOS) have demonstrated their efficiency in the copper-catalyzed asym. conjugate addn. of various dialkylzincs to α-aryl enones, α-aryl dienones, and cyclic dienones. Excellent 1,4- or 1,6-regioselectivities and enantioselectivities (up to 97% ee) were attained, even with challenging sterically hindered Michael acceptors.
Cited literature [13 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01188236
Contributor : Laurent Jonchère <>
Submitted on : Monday, October 19, 2015 - 4:20:58 PM
Last modification on : Wednesday, January 13, 2021 - 3:39:42 AM
Long-term archiving on: : Wednesday, January 20, 2016 - 10:41:20 AM
Contributor : Laurent Jonchère <>
Submitted on : Monday, October 19, 2015 - 4:20:58 PM
Last modification on : Wednesday, January 13, 2021 - 3:39:42 AM
Long-term archiving on: : Wednesday, January 20, 2016 - 10:41:20 AM
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