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Journal articles
Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions
Claire Germain
1
Thierry Guillaudeux
2, 3, 4
Elisabeth D. Galsgaard
5
Catherine Hervouet
1
Nedra Tekaya
1
Anne-Sophie Gallouët
2, 3, 4
Julien Fassy
1
Franck Bihl
1
Gwénola Poupon
1
Anne Lazzari
1
Pieter Spee
5
Fabienne Anjuère
1
Céline Pangault
2
Karin Tarte
2
Patrick Tas
6, 2
Luc Xerri
7
Veronique M Braud
1
Claire Germain 1
Author
Thierry Guillaudeux 2, 3, 4
Author
Elisabeth D. Galsgaard 5
Author
Catherine Hervouet 1
Author
Nedra Tekaya 1
Author
Anne-Sophie Gallouët 2, 3, 4
Author
Julien Fassy 1
Author
Franck Bihl 1
Author IdHAL : franck-bihl ORCID : https://orcid.org/0000-0002-8808-8152
Veronique M Braud 1
Author IdHAL : veronique-braud ResearcherId : http://www.researcherid.com/rid/I-4597-2013 ORCID : https://orcid.org/0000-0001-8213-3947
1
IPMC - Institut de pharmacologie moléculaire et cellulaire (CNRS-IPMC 660 Route des lucioles 06560 VALBONNE - France)
- UNS - Université Nice Sophia Antipolis (... - 2019) (Parc Valrose - BP 2135 - 06103 Nice cedex 2 - France)
- COMUE UCA - COMUE Université Côte d'Azur (2015 - 2019) (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7275 (France)
- UCA - Université Côte d'Azur (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
2
MiCa - Microenvironnement et cancer (INSERM UMR917, Campus Santé, Bât 2, Université de Rennes 1, 2 Avenue du Professeur Léon Bernard, 35043 Rennes, France - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U917 (101, rue de Tolbiac, 75013 Paris - France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
4
Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
5
Novo Nordisk Foundation Center for Biosustainability (Tuborg Havnevej 19,
2900 Hellerup - Denmark)
- DTU - Technical University of Denmark [Lyngby] (Anker Engelunds Vej 1, Building 101A, 2800 Kgs. Lyngby - Denmark)
6
CHU Pontchaillou [Rennes] (2 Rue Henri le Guilloux, 35000 Rennes - France)
7
CRCM - Centre de Recherche en Cancérologie de Marseille (27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09 - France)
- AMU - Aix Marseille Université : UM105 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- Institut Paoli-Calmettes : UMR7258 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1068 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7258 (France)
Abstract : Non-Hodgkin's lymphomas (NHLs) are malignant neoplasms which are clinically and biologically diverse. Their incidence is constantly increasing and despite treatment advances, there is a need for novel targeted therapies. Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs. LLT1 identifies GC B cells in reactive tonsils and lymph nodes and its expression is maintained in B-cell NHLs which derive from GC, including Burkitt lymphoma (BL), follicular lymphoma (FL), and GC-derived diffuse large B-cell lymphoma (DLBCL). We further show that LLT1 expression by tumors dampens natural killer (NK) cell functions following interaction with its receptor CD161, uncovering a potential immune escape mechanism. Our results pinpoint LLT1 as a novel biomarker of GC-derived B-cell NHLs and as a candidate target for innovative immunotherapies
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201947
Contributor : Laurent Jonchère <>
Submitted on : Friday, September 18, 2015 - 1:50:22 PM
Last modification on : Tuesday, October 13, 2020 - 3:11:07 AM
Contributor : Laurent Jonchère <>
Submitted on : Friday, September 18, 2015 - 1:50:22 PM
Last modification on : Tuesday, October 13, 2020 - 3:11:07 AM
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Identifiers
- HAL Id : hal-01201947, version 1
- DOI : 10.1080/2162402X.2015.1026503
- PUBMED : 26405582
Collections
UNIV-RENNES1 | CNRS | UNICE | U917 | BIOSIT | UR1-UFR-SVE | MICMAC | UNIV-COTEDAZUR | UNIV-RENNES | UNIV-AMU | CRCM
Citation
Claire Germain, Thierry Guillaudeux, Elisabeth D. Galsgaard, Catherine Hervouet, Nedra Tekaya, et al.. Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions. OncoImmunology, Taylor & Francis, 2015, 4 (8), pp.e1026503. ⟨10.1080/2162402X.2015.1026503⟩. ⟨hal-01201947⟩
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