Skip to Main content Skip to Navigation
Journal articles

Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions

Abstract : Non-Hodgkin's lymphomas (NHLs) are malignant neoplasms which are clinically and biologically diverse. Their incidence is constantly increasing and despite treatment advances, there is a need for novel targeted therapies. Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs. LLT1 identifies GC B cells in reactive tonsils and lymph nodes and its expression is maintained in B-cell NHLs which derive from GC, including Burkitt lymphoma (BL), follicular lymphoma (FL), and GC-derived diffuse large B-cell lymphoma (DLBCL). We further show that LLT1 expression by tumors dampens natural killer (NK) cell functions following interaction with its receptor CD161, uncovering a potential immune escape mechanism. Our results pinpoint LLT1 as a novel biomarker of GC-derived B-cell NHLs and as a candidate target for innovative immunotherapies
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201947
Contributor : Laurent Jonchère <>
Submitted on : Friday, September 18, 2015 - 1:50:22 PM
Last modification on : Tuesday, October 13, 2020 - 3:11:07 AM

Links full text

Identifiers

Citation

Claire Germain, Thierry Guillaudeux, Elisabeth D. Galsgaard, Catherine Hervouet, Nedra Tekaya, et al.. Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions. OncoImmunology, Taylor & Francis, 2015, 4 (8), pp.e1026503. ⟨10.1080/2162402X.2015.1026503⟩. ⟨hal-01201947⟩

Share

Metrics

Record views

229