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T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

Abstract : Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective. Cancer Immunol Res; 3(10); 1115-22. ©2015 AACR
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Thursday, October 15, 2015 - 5:06:35 PM
Last modification on : Thursday, February 25, 2021 - 9:46:04 AM

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Roch Houot, Liora Michal Schultz, Aurelien Marabelle, Holbrook Kohrt. T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition. Cancer Immunology Research, American Association for Cancer Research, 2015, 3 (10), pp.1115--1122. ⟨10.1158/2326-6066.CIR-15-0190⟩. ⟨hal-01216199⟩



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