Palladium-Catalyzed Iterative C[n.63743]H Bond Arylations: Synthesis of Medium-Size Heterocycles with a Bridgehead Nitrogen Atom
Abstract
Condensed N-heterocycles were prepd. by using iterative C[n.63743]H bond activation reactions catalyzed by palladium. The first step consists of a palladium-catalyzed direct desulfitative C[n.63743]H bond arylation of brominated N-benzylpyrrole derivs. with benzenesulfonyl chlorides. The presence of the bromine atom allows the formation in the second step of several N-heterocycles with five-, six-, or seven-membered rings by a palladium-catalyzed intramol. C[n.63743]H bond arylation.