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Journal Articles Angewandte Chemie International Edition Year : 2015

Iron-Catalyzed α-Alkylation of Ketones with Alcohols

Abstract

A general and benign iron-catalyzed α-alkylation reaction of ketones with primary alcohols has been developed. The key to success of the reaction is the use of a Knölker-type complex as catalyst (2 mol %) in the presence of Cs2 CO3 as base (10 mol %) under hydrogen-borrowing conditions. Using 2-aminobenzyl alcohol as alkylation reagent allows for the "green" synthesis of quinoline derivatives.

Dates and versions

hal-01216296 , version 1 (16-10-2015)

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Saravanakumar Elangovan, Jean-Baptiste Sortais, Matthias Beller, Christophe Darcel. Iron-Catalyzed α-Alkylation of Ketones with Alcohols. Angewandte Chemie International Edition, 2015, 54 (48), pp.14483-14486. ⟨10.1002/anie.201506698⟩. ⟨hal-01216296⟩
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