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Iron-Catalyzed α-Alkylation of Ketones with Alcohols

Abstract : A general and benign iron-catalyzed α-alkylation reaction of ketones with primary alcohols has been developed. The key to success of the reaction is the use of a Knölker-type complex as catalyst (2 mol %) in the presence of Cs2 CO3 as base (10 mol %) under hydrogen-borrowing conditions. Using 2-aminobenzyl alcohol as alkylation reagent allows for the "green" synthesis of quinoline derivatives.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01216296
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Submitted on : Friday, October 16, 2015 - 9:19:10 AM
Last modification on : Friday, July 10, 2020 - 4:21:56 PM

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Saravanakumar Elangovan, Jean-Baptiste Sortais, Matthias Beller, Christophe Darcel. Iron-Catalyzed α-Alkylation of Ketones with Alcohols. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2015, 54 (48), pp.14483-14486. ⟨10.1002/anie.201506698⟩. ⟨hal-01216296⟩

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