M. Braoudaki and F. Tzortzatou-stathopoulou, Tumorigenesis related to retroviral infections, The Journal of Infection in Developing Countries, vol.5, issue.11, pp.751-759, 2011.
DOI : 10.3855/jidc.1773

L. Wolff, R. Koller, X. Hu, and M. Anver, A Moloney Murine Leukemia Virus-Based Retrovirus with 4070A Long Terminal Repeat Sequences Induces a High Incidence of Myeloid as Well as Lymphoid Neoplasms, Journal of Virology, vol.77, issue.8, pp.4965-71, 2003.
DOI : 10.1128/JVI.77.8.4965-4971.2003

T. Suzuki, H. Shen, K. Akagi, H. Morse, J. Malley et al., New genes involved in cancer identified by retroviral tagging, Nature Genetics, vol.32, issue.1, pp.166-74, 2002.
DOI : 10.1038/ng949

A. Lund, G. Turner, A. Trubetskoy, E. Verhoeven, E. Wientjens et al., Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice, Nature Genetics, vol.32, issue.1, pp.160-165, 2002.
DOI : 10.1038/ng956

R. Kim, A. Trubetskoy, T. Suzuki, N. Jenkins, N. Copeland et al., Genome-Based Identification of Cancer Genes by Proviral Tagging in Mouse Retrovirus-Induced T-Cell Lymphomas, Journal of Virology, vol.77, issue.3, pp.2056-62, 2003.
DOI : 10.1128/JVI.77.3.2056-2062.2003

H. Mikkers, J. Allen, P. Knipscheer, L. Romeyn, A. Hart et al., High-throughput retroviral tagging to identify components of specific signaling pathways in cancer, Nature Genetics, vol.32, issue.1, pp.153-162, 2002.
DOI : 10.1038/ng950

R. Keswani, I. Pozdol, and D. Pack, Design of Hybrid Lipid/Retroviral-Like Particle Gene Delivery Vectors, Molecular Pharmaceutics, vol.10, issue.5, pp.1725-1760, 2013.
DOI : 10.1021/mp300561y

M. Cavazzana-calvo and A. Fischer, Gene therapy for severe combined immunodeficiency: are we there yet?, Journal of Clinical Investigation, vol.117, issue.6, pp.1456-65, 2007.
DOI : 10.1172/JCI30953

S. Aiyer, G. Swapna, N. Malani, J. Aramini, W. Schneider et al., Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction, Nucleic Acids Research, vol.42, issue.9, pp.5917-5945, 2014.
DOI : 10.1093/nar/gku175

E. Ashkar, S. , D. Rijck, J. Demeulemeester, J. Vets et al., BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements, Molecular Therapy - Nucleic Acids, vol.3, p.179, 2014.
DOI : 10.1038/mtna.2014.33

D. Purcell and M. Martin, Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity, J Virol, vol.67, pp.6365-78, 1993.

L. Houzet, J. Battini, E. Bernard, V. Thibert, and M. Mougel, A new retroelement constituted by a natural alternatively spliced RNA of murine replication-competent retroviruses, The EMBO Journal, vol.22, issue.18, pp.4866-75, 2003.
DOI : 10.1093/emboj/cdg450

N. Dorman and A. Lever, Comparison of Viral Genomic RNA Sorting Mechanisms in Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Moloney Murine Leukemia Virus, Journal of Virology, vol.74, issue.23, pp.11413-11420, 2000.
DOI : 10.1128/JVI.74.23.11413-11417.2000

S. Hocine, R. Singer, and D. Grunwald, RNA Processing and Export, Cold Spring Harbor Perspectives in Biology, vol.2, issue.12, p.752, 2010.
DOI : 10.1101/cshperspect.a000752

N. Pante, Nuclear Pore Complex Structure, Developmental Cell, vol.7, issue.6, pp.780-781, 2004.
DOI : 10.1016/j.devcel.2004.11.010

B. Montpetit, N. Thomsen, K. Helmke, M. Seeliger, J. Berger et al., A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export, Nature, vol.37, issue.7342, pp.238-280, 2011.
DOI : 10.1038/nature09862

D. Grunwald, R. Singer, and M. Rout, Nuclear export dynamics of RNA???protein complexes, Nature, vol.20, issue.7356, pp.333-374, 2011.
DOI : 10.1038/nature10318

K. Katenkamp, A. Berndt, W. Hindermann, H. Wunderlich, K. Haas et al., mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma, The Journal of Pathology, vol.203, issue.3, pp.771-780, 2004.
DOI : 10.1002/path.1589

N. Vitulo, C. Forcato, E. Carpinelli, A. Telatin, D. Campagna et al., A deep survey of alternative splicing in grape reveals changes in the splicing machinery related to tissue, stress condition and genotype, BMC Plant Biology, vol.14, issue.1, p.99, 2014.
DOI : 10.1093/nar/gks666

E. Grzybowska, Human intronless genes: Functional groups, associated diseases, evolution, and mRNA processing in absence of splicing, Biochemical and Biophysical Research Communications, vol.424, issue.1, pp.1-6, 2012.
DOI : 10.1016/j.bbrc.2012.06.092

M. Harris and T. Hope, RNA export: insights from viral models, Essays In Biochemistry, vol.36, pp.115-142, 2000.
DOI : 10.1042/bse0360115

B. Wang, D. Rekosh, and M. Hammarskjold, Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns, RNA, vol.21, issue.3, 2015.
DOI : 10.1261/rna.048520.114

F. Smagulova, S. Maurel, Z. Morichaud, C. Devaux, M. Mougel et al., The Highly Structured Encapsidation Signal of MuLV RNA is Involved in the Nuclear Export of its Unspliced RNA, Journal of Molecular Biology, vol.354, issue.5, pp.1118-1146, 2005.
DOI : 10.1016/j.jmb.2005.10.021

J. Levin, P. Grimley, J. Ramseur, and I. Berezesky, Deficiency of 60 to 70S RNA in murine leukemia virus particles assembled in cells treated with actinomycin D, J Virol, vol.14, pp.152-61, 1974.

L. Messer, J. Levin, and S. Chattopadhyay, Metabolism of viral RNA in murine leukemia virusinfected cells; evidence for differential stability of viral message and virion precursor RNA, J Virol, vol.40, pp.683-90, 1981.

H. Bartels and J. Luban, Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag -encoded RNA, Retrovirology, vol.11, issue.1, p.73, 2014.
DOI : 10.1186/PREACCEPT-8755229871261499

L. Pessel-vivares, M. Ferrer, S. Laine, and M. Mougel, MLV requires Tap/NXF1-dependent pathway to export its unspliced RNA to the cytoplasm and to express both spliced and unspliced RNAs, Retrovirology, vol.11, issue.1, p.21, 2014.
DOI : 10.3390/v5112767

T. Sakuma, J. Tonne, and Y. Ikeda, Murine Leukemia Virus Uses TREX Components for Efficient Nuclear Export of Unspliced Viral Transcripts, Viruses, vol.6, issue.3, pp.1135-1183, 2014.
DOI : 10.3390/v6031135

T. Sakuma, J. Davila, J. Malcolm, J. Kocher, J. Tonne et al., Murine Leukemia Virus Uses NXF1 for Nuclear Export of Spliced and Unspliced Viral Transcripts, Journal of Virology, vol.88, issue.8, pp.4069-82, 2014.
DOI : 10.1128/JVI.03584-13

G. Pilkington, K. Purzycka, J. Bear, L. Grice, S. Felber et al., Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element, Nucleic Acids Research, vol.42, issue.17, pp.11092-106, 2015.
DOI : 10.1093/nar/gku798

K. Dufu, M. Livingstone, J. Seebacher, S. Gygi, S. Wilson et al., ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex, Genes & Development, vol.24, issue.18, pp.2043-53, 2010.
DOI : 10.1101/gad.1898610

D. Gatfield, L. Hir, H. Schmitt, C. Braun, I. Kocher et al., The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila, Current Biology, vol.11, issue.21, pp.1716-1737, 2001.
DOI : 10.1016/S0960-9822(01)00532-2

L. Zhang, J. Shen, M. Guarnieri, A. Heroux, K. Yang et al., Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants, Protein Science, vol.419, issue.6, pp.1024-1055, 2007.
DOI : 10.1110/ps.072872007

N. Viphakone, G. Hautbergue, M. Walsh, C. Chang, A. Holland et al., TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export, Nature Communications, vol.38, p.1006, 2012.
DOI : 10.1038/ncomms2005

I. Ote, M. Lebrun, P. Vandevenne, S. Bontems, C. Medina-palazon et al., Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports mRNAs through the TAP/NXF1 Pathway, PLoS ONE, vol.17, issue.11, p.7882, 2009.
DOI : 10.1371/journal.pone.0007882.g009
URL : https://hal.archives-ouvertes.fr/inserm-00520156

Y. Huang and J. Steitz, Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA, Molecular Cell, vol.7, issue.4, pp.899-905, 2001.
DOI : 10.1016/S1097-2765(01)00233-7

J. Sanford, N. Gray, K. Beckmann, and J. Caceres, A novel role for shuttling SR proteins in mRNA translation, Genes & Development, vol.18, issue.7, pp.755-68, 2004.
DOI : 10.1101/gad.286404

Y. Zheng, H. Yu, and B. Peterlin, Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells, Nature Cell Biology, vol.5, issue.7, pp.611-619, 2003.
DOI : 10.1038/9479

C. Swanson, B. Puffer, K. Ahmad, R. Doms, and M. Malim, Retroviral mRNA nuclear export elements regulate protein function and virion assembly, The EMBO Journal, vol.7, issue.13, pp.2632-2672, 2004.
DOI : 10.1038/415088a

N. Sherer, C. Swanson, S. Papaioannou, and M. Malim, Matrix Mediates the Functional Link between Human Immunodeficiency Virus Type 1 RNA Nuclear Export Elements and the Assembly Competency of Gag in Murine Cells, Journal of Virology, vol.83, issue.17, pp.8525-8560, 2009.
DOI : 10.1128/JVI.00699-09

L. Cupelli, S. Okenquist, A. Trubetskoy, and J. Lenz, The secondary structure of the R region of a murine leukemia virus is important for stimulation of long terminal repeat-driven gene expression, J Virol, vol.72, pp.7807-7821, 1998.

L. Cupelli and J. Lenz, Transcriptional initiation and postinitiation effects of murine leukemia virus long terminal repeat R-region sequences, J Virol, vol.65, pp.6961-6969, 1991.

M. Mougel, N. Tounekti, J. Darlix, J. Paoletti, B. Ehresmann et al., Conformational analysis of the 5' leader and the gag initiation site of Mo-MuLV RNA and allosteric transitions induced by dimerization, Nucleic Acids Research, vol.21, issue.20, pp.4677-84, 1993.
DOI : 10.1093/nar/21.20.4677

A. Trubetskoy, S. Okenquist, and J. Lenz, R region sequences in the long terminal repeat of a murine retrovirus specifically increase expression of unspliced RNAs, J Virol, vol.73, pp.3477-83, 1999.

D. Tapia, M. Metzler, V. Mougel, M. Ehresmann, B. Ehresmann et al., Dimerization of MoMuLV genomic RNA: redefinition of the role of the palindromic stem-loop H1 (278-303) and new roles for stem-loops H2, Biochemistry, vol.37, pp.310-352, 1998.

A. Prats, C. Roy, P. Wang, M. Erard, V. Housset et al., cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA, Journal of Virology, vol.64, pp.774-83, 1990.

A. Rein, Take two, Nature Structural & Molecular Biology, vol.34, issue.11, pp.1034-1039, 2004.
DOI : 10.1017/S1355838201001881

M. Mougel, Y. Zhang, and E. Barklis, Cis-active structural motifs involved in specific encapsidation of Moloney Murine Leukemia Virus RNA, J Virol, vol.70, pp.5043-50, 1996.

R. Mann and D. Baltimore, Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs, J Virol, vol.54, pp.401-408, 1985.

R. Mann, R. Mulligan, and D. Baltimore, Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus, Cell, vol.33, issue.1, pp.153-162, 1983.
DOI : 10.1016/0092-8674(83)90344-6

A. Rein, D. Harvin, J. Mirro, S. Ernst, and R. Gorelick, Evidence that a central domain of nucleocapsid protein is required for RNA packaging in murine leukemia virus, J Virol, vol.68, pp.6124-6133, 1994.

N. Tounekti, M. Mougel, C. Roy, R. Marquet, J. Darlix et al., Effect of dimerization on the conformation of the encapsidation Psi domain of Moloney murine leukemia virus RNA, Journal of Molecular Biology, vol.223, issue.1, pp.205-225, 1992.
DOI : 10.1016/0022-2836(92)90726-Z

Y. Miyazaki, E. Garcia, S. King, K. Iyalla, K. Loeliger et al., An RNA Structural Switch Regulates Diploid Genome Packaging by Moloney Murine Leukemia Virus, Journal of Molecular Biology, vol.396, issue.1, pp.141-52, 2010.
DOI : 10.1016/j.jmb.2009.11.033

D. Souza, V. Melamed, J. Habib, D. Pullen, K. Wallace et al., Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition, J Mol Biol, vol.314, pp.217-249, 2001.

E. Basyuk, S. Boulon, S. Pedersen, F. Bertrand, E. Vestergaard-rasmussen et al., The Packaging Signal of MLV is an Integrated Module that Mediates Intracellular Transport of Genomic RNAs, Journal of Molecular Biology, vol.354, issue.2, pp.330-339, 2005.
DOI : 10.1016/j.jmb.2005.09.071

P. Gruter, C. Tabernero, C. Von-kobbe, C. Schmitt, C. Saavedra et al., TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus, Molecular Cell, vol.1, issue.5, pp.649-59, 1998.
DOI : 10.1016/S1097-2765(00)80065-9

S. Hoshi, T. Odawara, M. Oshima, Y. Kitamura, H. Takizawa et al., cis-Elements Involved in Expression of Unspliced RNA in Moloney Murine Leukemia Virus, Biochemical and Biophysical Research Communications, vol.290, issue.3, pp.1139-1183, 2002.
DOI : 10.1006/bbrc.2001.6326

T. Maetzig, M. Galla, C. Baum, and A. Schambach, Gammaretroviral Vectors: Biology, Technology and Application, Viruses, vol.3, issue.12, pp.677-713, 2011.
DOI : 10.3390/v3060677
URL : http://doi.org/10.3390/v3060677

N. Volkova, E. Fomina, V. Smolnikova, N. Zinovieva, and I. Fomin, The U3 Region of Moloney Murine Leukemia Virus Contains Position-independent Cis-acting Sequences Involved in the Nuclear Export of Full-length Viral Transcripts, Journal of Biological Chemistry, vol.289, issue.29, pp.20158-69, 2014.
DOI : 10.1074/jbc.M113.545855

A. Machinaga and S. Takase-yoden, -mRNA is affected by its splicing, Microbiology and Immunology, vol.85, issue.8, pp.474-82, 2014.
DOI : 10.1111/1348-0421.12170

N. Yamamoto and S. Takase-yoden, Friend murine leukemia virus A8 regulates Env protein expression through an intron sequence, Virology, vol.385, issue.1, pp.115-140, 2009.
DOI : 10.1016/j.virol.2008.11.040

S. Hull and K. Boris-lawrie, Analysis of synergy between divergent simple retrovirus posttranscriptional control elements, Virology, vol.317, issue.1, pp.146-54, 2003.
DOI : 10.1016/j.virol.2003.08.037

A. Schambach, H. Wodrich, M. Hildinger, J. Bohne, H. Krausslich et al., Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors, Molecular Therapy, vol.2, issue.5, pp.435-480, 2000.
DOI : 10.1006/mthe.2000.0191

M. Hammarskjold, H. Li, D. Rekosh, and S. Prasad, Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron, J Virol, vol.68, pp.951-959, 1994.