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Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones

Kaiwu Dong Rui Sang Jean-François Soulé 1 Christian Bruneau 1 Robert Franke Ralf Jackstell Matthias Beller 2
1 ISCR - Institut des Sciences Chimiques de Rennes
2 LIKAT Rostock - Leibniz-Institut für Katalyse
Abstract : An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene
Keywords : benzoin condensation Catalysis domino reactions hydroformylation olefins
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01224515
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, November 4, 2015 - 5:14:05 PM
Last modification on : Saturday, July 11, 2020 - 3:16:47 AM

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UNIV-RENNES1 | CNRS | ISCR | ISCR-OMC | INC-CNRS | UR1-UFR-SPM | UNIV-RENNES | INSA-GROUPE | INSA-RENNES

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Kaiwu Dong, Rui Sang, Jean-François Soulé, Christian Bruneau, Robert Franke, et al.. Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (50), pp.18033-18037. ⟨10.1002/chem.201502982⟩. ⟨hal-01224515⟩

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