Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones - Archive ouverte HAL Access content directly
Journal Articles Chemistry - A European Journal Year : 2015

Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones

Kaiwu Dong
  • Function : Author
Rui Sang
  • Function : Author
Robert Franke
  • Function : Author
Ralf Jackstell
  • Function : Author
Matthias Beller
  • Function : Author
  • PersonId : 947488

Abstract

An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene

Dates and versions

hal-01224515 , version 1 (04-11-2015)

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Kaiwu Dong, Rui Sang, Jean-François Soulé, Christian Bruneau, Robert Franke, et al.. Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones. Chemistry - A European Journal, 2015, 21 (50), pp.18033-18037. ⟨10.1002/chem.201502982⟩. ⟨hal-01224515⟩
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